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Changes in lipid profiles of liver microsomes of rats following intratracheal administration of DDT or endosulfan.

Publication ,  Journal Article
Narayan, S; Dani, HM; Misra, UK
Published in: J Environ Sci Health B
April 1990

The effect of intratracheal administration of DDT (5 mg/100 g body weight) or endosulfan (1 mg/100 g body weight) to rats for three consecutive days, has been studied on liver lipid metabolism. The administration of DDT but not endosulfan significantly increased the liver weight and the microsomal protein contents. Both DDT and endosulfan treatments significantly increased the contents of microsomal phosphatidylcholine (PC), total-free- and esterified cholesterol. The distribution of unsaturated fatty acids of microsomal PC and PE was increased by DDT treatment. The intratracheal administration of DDT caused fatty infiltration of liver which was probably due to increased synthesis of triglycerides (TG). This is supported by the increased incorporation of radioactive palmitate-1-14C into microsomal TG. However, the increased incorporation of palmitate-1-14C into microsomal PC and phosphatidylethanolamine (PE) after the DDT treatment, was due to the increased transacylation reaction supported by the decreased activity of microsomal phospholipase A. The intratracheal administration of endosulfan did not have pronounced effect on liver fatty infiltration, or transacylation reaction in microsomal PC and PE. However, the results have shown that the treatments of DDT or endosulfan increased the PC contents and the incorporation of radioactive [methyl-3H]choline into PC of microsomes, resulting the increased synthesis of PC via CDPcholine pathway. Thus, the intratracheally administered DDT or endosulfan to rats showed that both the insecticides cause manifestations in the biochemistry of microsomal membrane lipids, although the effects of DDT being more pronounced. Therefore, the translocation effects of these insecticides or metabolites from lung to liver is established.

Duke Scholars

Published In

J Environ Sci Health B

DOI

ISSN

0360-1234

Publication Date

April 1990

Volume

25

Issue

2

Start / End Page

243 / 257

Location

England

Related Subject Headings

  • Toxicology
  • Rats, Inbred Strains
  • Rats
  • Phospholipases A
  • Phosphatidylethanolamines
  • Phosphatidylcholines
  • Microsomes, Liver
  • Male
  • Lipids
  • Lipid Metabolism
 

Citation

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Narayan, S., Dani, H. M., & Misra, U. K. (1990). Changes in lipid profiles of liver microsomes of rats following intratracheal administration of DDT or endosulfan. J Environ Sci Health B, 25(2), 243–257. https://doi.org/10.1080/03601239009372687
Narayan, S., H. M. Dani, and U. K. Misra. “Changes in lipid profiles of liver microsomes of rats following intratracheal administration of DDT or endosulfan.J Environ Sci Health B 25, no. 2 (April 1990): 243–57. https://doi.org/10.1080/03601239009372687.
Narayan S, Dani HM, Misra UK. Changes in lipid profiles of liver microsomes of rats following intratracheal administration of DDT or endosulfan. J Environ Sci Health B. 1990 Apr;25(2):243–57.
Narayan, S., et al. “Changes in lipid profiles of liver microsomes of rats following intratracheal administration of DDT or endosulfan.J Environ Sci Health B, vol. 25, no. 2, Apr. 1990, pp. 243–57. Pubmed, doi:10.1080/03601239009372687.
Narayan S, Dani HM, Misra UK. Changes in lipid profiles of liver microsomes of rats following intratracheal administration of DDT or endosulfan. J Environ Sci Health B. 1990 Apr;25(2):243–257.
Journal cover image

Published In

J Environ Sci Health B

DOI

ISSN

0360-1234

Publication Date

April 1990

Volume

25

Issue

2

Start / End Page

243 / 257

Location

England

Related Subject Headings

  • Toxicology
  • Rats, Inbred Strains
  • Rats
  • Phospholipases A
  • Phosphatidylethanolamines
  • Phosphatidylcholines
  • Microsomes, Liver
  • Male
  • Lipids
  • Lipid Metabolism