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Subject-Specific Multiscale Modeling to Investigate Effects of Transcranial Magnetic Stimulation.

Publication ,  Journal Article
Goodwin, BD; Butson, CR
Published in: Neuromodulation
December 2015

OBJECTIVE: Transcranial magnetic stimulation (TMS) is an effective intervention in noninvasive neuromodulation used to treat a number of neurophysiological disorders. Predicting the spatial extent to which neural tissue is affected by TMS remains a challenge. The goal of this study was to develop a computational model to predict specific locations of neural tissue that are activated during TMS. Using this approach, we assessed the effects of changing TMS coil orientation and waveform. MATERIALS AND METHODS: We integrated novel techniques to develop a subject-specific computational model, which contains three main components: 1) a figure-8 coil (Magstim, Magstim Company Limited, Carmarthenshire, UK); 2) an electromagnetic, time-dependent, nonhomogeneous, finite element model of the whole head; and 3) an adaptation of a previously published pyramidal cell neuron model. We then used our modeling approach to quantify the spatial extent of affected neural tissue for changes in TMS coil rotation and waveform. RESULTS: We found that our model shows more detailed predictions than previously published models, which underestimate the spatial extent of neural activation. Our results suggest that fortuitous sites of neural activation occur for all tested coil orientations. Additionally, our model predictions show that excitability of individual neural elements changes with a coil rotation of ±15°. CONCLUSIONS: Our results indicate that the extent of neuromodulation is more widespread than previous published models suggest. Additionally, both specific locations in cortex and the extent of stimulation in cortex depend on coil orientation to within ±15° at a minimum. Lastly, through computational means, we are able to provide insight into the effects of TMS at a cellular level, which is currently unachievable by imaging modalities.

Duke Scholars

Published In

Neuromodulation

DOI

EISSN

1525-1403

Publication Date

December 2015

Volume

18

Issue

8

Start / End Page

694 / 704

Location

United States

Related Subject Headings

  • Transcranial Magnetic Stimulation
  • Neurons
  • Neurology & Neurosurgery
  • Motor Cortex
  • Models, Neurological
  • Humans
  • Fourier Analysis
  • Computer Simulation
  • Brain Mapping
  • 3209 Neurosciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Goodwin, B. D., & Butson, C. R. (2015). Subject-Specific Multiscale Modeling to Investigate Effects of Transcranial Magnetic Stimulation. Neuromodulation, 18(8), 694–704. https://doi.org/10.1111/ner.12296
Goodwin, Brian D., and Christopher R. Butson. “Subject-Specific Multiscale Modeling to Investigate Effects of Transcranial Magnetic Stimulation.Neuromodulation 18, no. 8 (December 2015): 694–704. https://doi.org/10.1111/ner.12296.
Goodwin BD, Butson CR. Subject-Specific Multiscale Modeling to Investigate Effects of Transcranial Magnetic Stimulation. Neuromodulation. 2015 Dec;18(8):694–704.
Goodwin, Brian D., and Christopher R. Butson. “Subject-Specific Multiscale Modeling to Investigate Effects of Transcranial Magnetic Stimulation.Neuromodulation, vol. 18, no. 8, Dec. 2015, pp. 694–704. Pubmed, doi:10.1111/ner.12296.
Goodwin BD, Butson CR. Subject-Specific Multiscale Modeling to Investigate Effects of Transcranial Magnetic Stimulation. Neuromodulation. 2015 Dec;18(8):694–704.
Journal cover image

Published In

Neuromodulation

DOI

EISSN

1525-1403

Publication Date

December 2015

Volume

18

Issue

8

Start / End Page

694 / 704

Location

United States

Related Subject Headings

  • Transcranial Magnetic Stimulation
  • Neurons
  • Neurology & Neurosurgery
  • Motor Cortex
  • Models, Neurological
  • Humans
  • Fourier Analysis
  • Computer Simulation
  • Brain Mapping
  • 3209 Neurosciences