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Comparisons of the uptake and in-hospital outcomes associated with second-generation drug-eluting stents between men and women: results from the CathPCI Registry.

Publication ,  Journal Article
Baber, U; Giustino, G; Wang, T; Grines, C; McCoy, LA; Saha-Chaudhuri, P; Best, P; Skelding, KA; Ortega, R; Chieffo, A; Mehilli, J; Tcheng, J ...
Published in: Coron Artery Dis
September 2016

OBJECTIVES: We sought to examine trends in use and outcomes of second-generation drug-eluting stents (DES) across sexes in a contemporary percutaneous coronary intervention (PCI) cohort. BACKGROUND: Sparse female enrollment in trials comparing first-generation versus second-generation DES may influence clinical decision making at the time of PCI. METHODS: We studied patients undergoing PCI with DES enrolled in the CathPCI Registry between July 2009 and March 2013. We compared the prevalence of second-generation DES use by sex over time. Outcomes included procedural success, post-PCI bleeding, and vascular complications. Associations between sex and DES type on outcomes were assessed using logistic regression with formal interaction tests. RESULTS: Compared with men (n=1 129 122; 67.7%), women (n=538 835; 32.3%) were older, with a higher prevalence of diabetes mellitus, peripheral vascular, and chronic kidney disease. Although use of second-generation DES increased among both men and women over time, use was higher among men in the first 1.5 years, with no differences thereafter. There were no differences in procedural success, bleeding, or vascular complications across sexes between first-generation and second-generation DES. CONCLUSION: Uptake of second-generation DES increased over time in women, with comparable in-hospital benefits as first-generation DES across sexes.

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Published In

Coron Artery Dis

DOI

EISSN

1473-5830

Publication Date

September 2016

Volume

27

Issue

6

Start / End Page

442 / 448

Location

England

Related Subject Headings

  • United States
  • Treatment Outcome
  • Sex Factors
  • Risk Factors
  • Registries
  • Prosthesis Design
  • Prevalence
  • Practice Patterns, Physicians'
  • Percutaneous Coronary Intervention
  • Middle Aged
 

Citation

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Baber, U., Giustino, G., Wang, T., Grines, C., McCoy, L. A., Saha-Chaudhuri, P., … Mehran, R. (2016). Comparisons of the uptake and in-hospital outcomes associated with second-generation drug-eluting stents between men and women: results from the CathPCI Registry. Coron Artery Dis, 27(6), 442–448. https://doi.org/10.1097/MCA.0000000000000376
Baber, Usman, Gennaro Giustino, Tracy Wang, Cindy Grines, Lisa A. McCoy, Paramita Saha-Chaudhuri, Patricia Best, et al. “Comparisons of the uptake and in-hospital outcomes associated with second-generation drug-eluting stents between men and women: results from the CathPCI Registry.Coron Artery Dis 27, no. 6 (September 2016): 442–48. https://doi.org/10.1097/MCA.0000000000000376.
Baber U, Giustino G, Wang T, Grines C, McCoy LA, Saha-Chaudhuri P, et al. Comparisons of the uptake and in-hospital outcomes associated with second-generation drug-eluting stents between men and women: results from the CathPCI Registry. Coron Artery Dis. 2016 Sep;27(6):442–8.
Baber, Usman, et al. “Comparisons of the uptake and in-hospital outcomes associated with second-generation drug-eluting stents between men and women: results from the CathPCI Registry.Coron Artery Dis, vol. 27, no. 6, Sept. 2016, pp. 442–48. Pubmed, doi:10.1097/MCA.0000000000000376.
Baber U, Giustino G, Wang T, Grines C, McCoy LA, Saha-Chaudhuri P, Best P, Skelding KA, Ortega R, Chieffo A, Mehilli J, Tcheng J, Mehran R. Comparisons of the uptake and in-hospital outcomes associated with second-generation drug-eluting stents between men and women: results from the CathPCI Registry. Coron Artery Dis. 2016 Sep;27(6):442–448.

Published In

Coron Artery Dis

DOI

EISSN

1473-5830

Publication Date

September 2016

Volume

27

Issue

6

Start / End Page

442 / 448

Location

England

Related Subject Headings

  • United States
  • Treatment Outcome
  • Sex Factors
  • Risk Factors
  • Registries
  • Prosthesis Design
  • Prevalence
  • Practice Patterns, Physicians'
  • Percutaneous Coronary Intervention
  • Middle Aged