Skip to main content
Journal cover image

Laser-assisted delivery of vitamin C, vitamin E, and ferulic acid formula serum decreases fractional laser postoperative recovery by increased beta fibroblast growth factor expression.

Publication ,  Journal Article
Waibel, JS; Mi, Q-S; Ozog, D; Qu, L; Zhou, L; Rudnick, A; Al-Niaimi, F; Woodward, J; Campos, V; Mordon, S
Published in: Lasers Surg Med
March 2016

BACKGROUND AND OBJECTIVE: Laser-assisted drug delivery is an emerging technology to achieve greater penetration by existing topical medications to reach desired targets in the tissue. The objective of this research was to study whether laser-assisted delivery of Vitamin C, E, and Ferulic immediately postoperatively of fractional ablative laser could improve wound healing. Secondary objectives were to evaluate the potential molecular markers involved in this wound-healing process. STUDY DESIGN/MATERIAL AND METHODS: A double blinded, prospective, single center, randomized split face trial of Vitamin C, E, and Ferulic topical formula #740019 to decrease postoperative recovery time in fractional ablative laser resurfacing for photo damage. Fifteen healthy men and women of ages 30-55 years were treated with the Vitamin C, E, and Ferulic acid serum to one side of face and vehicle to the other side of face, within 2 minutes immediately after fractional ablative CO2 laser surgery and daily during the healing process. Patients were evaluated daily on days 1-7 using photographs, patient questionnaires, and molecular evaluation. RESULTS: Clinically, postoperative Vitamin C, E, and Ferulic delivery resulted in decreased edema versus vehicle on postoperative day 7 and decreased erythema versus vehicle on postoperative days 3 and 5. Molecularly, the expression of basic fibroblast growth factor (bFGF) was significantly increased at day 5 on the lesion treated with Vitamin C, E, and Ferulic acid serum compared to vehicle control on the other side. CONCLUSION: This is first study to show that Vitamin C, E, and Ferulic acid correlate with more rapid wound healing post-fractional ablative laser. Elevated bFGF could be involved in the Vitamin C, E, and Ferulic acid-induced rapid wound healing.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Lasers Surg Med

DOI

EISSN

1096-9101

Publication Date

March 2016

Volume

48

Issue

3

Start / End Page

238 / 244

Location

United States

Related Subject Headings

  • Wound Healing
  • Vitamin E
  • Treatment Outcome
  • Skin Aging
  • Skin
  • Prospective Studies
  • Pilot Projects
  • Middle Aged
  • Male
  • Lasers, Gas
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Waibel, J. S., Mi, Q.-S., Ozog, D., Qu, L., Zhou, L., Rudnick, A., … Mordon, S. (2016). Laser-assisted delivery of vitamin C, vitamin E, and ferulic acid formula serum decreases fractional laser postoperative recovery by increased beta fibroblast growth factor expression. Lasers Surg Med, 48(3), 238–244. https://doi.org/10.1002/lsm.22448
Waibel, Jill S., Qing-Sheng Mi, David Ozog, Le Qu, Li Zhou, Ashley Rudnick, Firas Al-Niaimi, Julie Woodward, Valerie Campos, and Serge Mordon. “Laser-assisted delivery of vitamin C, vitamin E, and ferulic acid formula serum decreases fractional laser postoperative recovery by increased beta fibroblast growth factor expression.Lasers Surg Med 48, no. 3 (March 2016): 238–44. https://doi.org/10.1002/lsm.22448.
Waibel JS, Mi Q-S, Ozog D, Qu L, Zhou L, Rudnick A, Al-Niaimi F, Woodward J, Campos V, Mordon S. Laser-assisted delivery of vitamin C, vitamin E, and ferulic acid formula serum decreases fractional laser postoperative recovery by increased beta fibroblast growth factor expression. Lasers Surg Med. 2016 Mar;48(3):238–244.
Journal cover image

Published In

Lasers Surg Med

DOI

EISSN

1096-9101

Publication Date

March 2016

Volume

48

Issue

3

Start / End Page

238 / 244

Location

United States

Related Subject Headings

  • Wound Healing
  • Vitamin E
  • Treatment Outcome
  • Skin Aging
  • Skin
  • Prospective Studies
  • Pilot Projects
  • Middle Aged
  • Male
  • Lasers, Gas