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Glutathione-S-transferase polymorphisms and risk of squamous-cell carcinoma of the head and neck.

Publication ,  Journal Article
Cheng, L; Sturgis, EM; Eicher, SA; Char, D; Spitz, MR; Wei, Q
Published in: Int J Cancer
June 21, 1999

Differences in genetic susceptibility to tobacco-induced carcinogenesis appear to modulate an individual's risk of squamous-cell carcinoma of the head and neck (SCCHN). Risk for SCCHN may be associated with the null alleles of the carcinogen-metabolizing genes glutathione-S-transferase (GST) T1 and GSTM1. In this study, we evaluated the association between GSTM1 and GSTT1 null genotypes and risk of SCCHN in a matched case-control study of 162 patients with SCCHN and 315 healthy controls. Our results showed that 53.1% of cases and 42.9% of controls were null for GSTM1, whereas 32.7% of cases and 17.5% of controls were null for GSTT1 (p < 0.05 and p < 0.001, respectively). Furthermore, 19.8% of cases but only 7.9% of controls were null for both genes (p < 0.001). Multivariate analysis using logistic regression models, including age, sex, ethnicity, smoking status, alcohol status and GST genotypes, showed that both of these genotypes remained independent risk factors for disease [adjusted odds ratios (ORs) = 1.50 and 2.27, respectively; 95% confidence intervals (CIs) = 1.01-2.23 and 1.43-3.60, respectively). When the genotypes were divided into neither null, either null or both null, there was a dose-response relationship (adjusted OR = 1.50, 95% CI = 0.98-2.30) for the either-null group and (adjusted OR = 3.64, 95% CI = 1.94-6.84) for the both-null group (p < 0.001, trend test). Our findings suggest that the GSTM1 and GSTT1 null genotypes are independent risk factors for SCCHN and markers for genetic susceptibility to tobacco-induced carcinogenesis.

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Published In

Int J Cancer

DOI

ISSN

0020-7136

Publication Date

June 21, 1999

Volume

84

Issue

3

Start / End Page

220 / 224

Location

United States

Related Subject Headings

  • Risk Factors
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Head and Neck Neoplasms
  • Glutathione Transferase
  • Genotype
  • Female
 

Citation

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Cheng, L., Sturgis, E. M., Eicher, S. A., Char, D., Spitz, M. R., & Wei, Q. (1999). Glutathione-S-transferase polymorphisms and risk of squamous-cell carcinoma of the head and neck. Int J Cancer, 84(3), 220–224. https://doi.org/10.1002/(sici)1097-0215(19990621)84:3<220::aid-ijc4>3.0.co;2-s
Cheng, L., E. M. Sturgis, S. A. Eicher, D. Char, M. R. Spitz, and Q. Wei. “Glutathione-S-transferase polymorphisms and risk of squamous-cell carcinoma of the head and neck.Int J Cancer 84, no. 3 (June 21, 1999): 220–24. https://doi.org/10.1002/(sici)1097-0215(19990621)84:3<220::aid-ijc4>3.0.co;2-s.
Cheng L, Sturgis EM, Eicher SA, Char D, Spitz MR, Wei Q. Glutathione-S-transferase polymorphisms and risk of squamous-cell carcinoma of the head and neck. Int J Cancer. 1999 Jun 21;84(3):220–4.
Cheng, L., et al. “Glutathione-S-transferase polymorphisms and risk of squamous-cell carcinoma of the head and neck.Int J Cancer, vol. 84, no. 3, June 1999, pp. 220–24. Pubmed, doi:10.1002/(sici)1097-0215(19990621)84:3<220::aid-ijc4>3.0.co;2-s.
Cheng L, Sturgis EM, Eicher SA, Char D, Spitz MR, Wei Q. Glutathione-S-transferase polymorphisms and risk of squamous-cell carcinoma of the head and neck. Int J Cancer. 1999 Jun 21;84(3):220–224.
Journal cover image

Published In

Int J Cancer

DOI

ISSN

0020-7136

Publication Date

June 21, 1999

Volume

84

Issue

3

Start / End Page

220 / 224

Location

United States

Related Subject Headings

  • Risk Factors
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Head and Neck Neoplasms
  • Glutathione Transferase
  • Genotype
  • Female