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Knotty Zika Virus Blocks Exonuclease to Produce Subgenomic Flaviviral RNAs.

Publication ,  Journal Article
Gokhale, NS; Horner, SM
Published in: Cell Host Microbe
January 11, 2017

In a recent issue of Science, Akiyama et al. (2016) prove the existence of a pseudoknot that stabilizes a nuclease-resistant RNA structure in the 3' untranslated region of Zika virus. This reinforced structure blocks the 5'→3' exonuclease Xrn1 for the production of pathogenic subgenomic flaviviral RNAs.

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Published In

Cell Host Microbe

DOI

EISSN

1934-6069

Publication Date

January 11, 2017

Volume

21

Issue

1

Start / End Page

1 / 2

Location

United States

Related Subject Headings

  • Zika Virus Infection
  • Zika Virus
  • RNA, Viral
  • RNA Stability
  • Nucleic Acid Conformation
  • Immunology
  • Host-Pathogen Interactions
  • Exoribonucleases
  • 3207 Medical microbiology
  • 3107 Microbiology
 

Citation

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Gokhale, N. S., & Horner, S. M. (2017). Knotty Zika Virus Blocks Exonuclease to Produce Subgenomic Flaviviral RNAs. Cell Host Microbe, 21(1), 1–2. https://doi.org/10.1016/j.chom.2016.12.013
Gokhale, Nandan S., and Stacy M. Horner. “Knotty Zika Virus Blocks Exonuclease to Produce Subgenomic Flaviviral RNAs.Cell Host Microbe 21, no. 1 (January 11, 2017): 1–2. https://doi.org/10.1016/j.chom.2016.12.013.
Gokhale NS, Horner SM. Knotty Zika Virus Blocks Exonuclease to Produce Subgenomic Flaviviral RNAs. Cell Host Microbe. 2017 Jan 11;21(1):1–2.
Gokhale, Nandan S., and Stacy M. Horner. “Knotty Zika Virus Blocks Exonuclease to Produce Subgenomic Flaviviral RNAs.Cell Host Microbe, vol. 21, no. 1, Jan. 2017, pp. 1–2. Pubmed, doi:10.1016/j.chom.2016.12.013.
Gokhale NS, Horner SM. Knotty Zika Virus Blocks Exonuclease to Produce Subgenomic Flaviviral RNAs. Cell Host Microbe. 2017 Jan 11;21(1):1–2.
Journal cover image

Published In

Cell Host Microbe

DOI

EISSN

1934-6069

Publication Date

January 11, 2017

Volume

21

Issue

1

Start / End Page

1 / 2

Location

United States

Related Subject Headings

  • Zika Virus Infection
  • Zika Virus
  • RNA, Viral
  • RNA Stability
  • Nucleic Acid Conformation
  • Immunology
  • Host-Pathogen Interactions
  • Exoribonucleases
  • 3207 Medical microbiology
  • 3107 Microbiology