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Efficacy of aspirin (325 mg) + omeprazole (40 mg) in treating coronary artery disease.

Publication ,  Journal Article
Sharma, T; Bliden, K; Chaudhary, R; Tantry, U; Gurbel, PA
Published in: Expert Opin Pharmacother
January 2017

Aspirin is indicated for primary and secondary prevention of cardiovascular diseases (CVD) by major guidelines. However, its use may be associated with gastrointestinal (GI) toxicities, including, but not limited to, GI bleeding. This may lead to increased morbidity and mortality, as well as diminished compliance, which again leads to increased risk of major cardiovascular events. Modified formulations of aspirin often have comparable risks of GI toxicity despite their dose or formulation and have had limited success to prevent GI toxicities. Simultaneous treatment with Proton pump inhibitors (PPIs) has been used successfully to prevent GI toxicities from aspirin. However, addition of an extra medication may lead to lower compliance and hence ineffective or less than optimal treatment. Areas covered: After a selective literature search, a brief review of the available evidence regarding GI toxicity of aspirin and the protective effects of PPIs was conducted. The concept of combination tablets, and the available data about Aralez Pharmaceuticals' YOSPRALA (aspirin (81 mg or 325 mg) and omeprazole (40 mg) fixed dose combination tablet being evaluated for secondary prevention of cardiovascular and cerebrovascular events in patients at risk for GI complications of aspirin therapy) is also presented. Expert opinion: The available evidence suggests that PPIs are the best option to prevent aspirin-related GI toxicities, but compliance is low in people who are prescribed both aspirin and PPI. Combination tablets containing both aspirin and a PPI may be a good option for providing protection against GI toxicities in people who require aspirin for secondary prevention of cardiovascular diseases.

Duke Scholars

Published In

Expert Opin Pharmacother

DOI

EISSN

1744-7666

Publication Date

January 2017

Volume

18

Issue

1

Start / End Page

123 / 131

Location

England

Related Subject Headings

  • Secondary Prevention
  • Proton Pump Inhibitors
  • Platelet Aggregation Inhibitors
  • Pharmacology & Pharmacy
  • Omeprazole
  • Humans
  • Gastrointestinal Hemorrhage
  • Gastrointestinal Diseases
  • Coronary Artery Disease
  • Cardiovascular Diseases
 

Citation

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Sharma, T., Bliden, K., Chaudhary, R., Tantry, U., & Gurbel, P. A. (2017). Efficacy of aspirin (325 mg) + omeprazole (40 mg) in treating coronary artery disease. Expert Opin Pharmacother, 18(1), 123–131. https://doi.org/10.1080/14656566.2016.1269747
Sharma, Tushar, Kevin Bliden, Rahul Chaudhary, Udaya Tantry, and Paul A. Gurbel. “Efficacy of aspirin (325 mg) + omeprazole (40 mg) in treating coronary artery disease.Expert Opin Pharmacother 18, no. 1 (January 2017): 123–31. https://doi.org/10.1080/14656566.2016.1269747.
Sharma T, Bliden K, Chaudhary R, Tantry U, Gurbel PA. Efficacy of aspirin (325 mg) + omeprazole (40 mg) in treating coronary artery disease. Expert Opin Pharmacother. 2017 Jan;18(1):123–31.
Sharma, Tushar, et al. “Efficacy of aspirin (325 mg) + omeprazole (40 mg) in treating coronary artery disease.Expert Opin Pharmacother, vol. 18, no. 1, Jan. 2017, pp. 123–31. Pubmed, doi:10.1080/14656566.2016.1269747.
Sharma T, Bliden K, Chaudhary R, Tantry U, Gurbel PA. Efficacy of aspirin (325 mg) + omeprazole (40 mg) in treating coronary artery disease. Expert Opin Pharmacother. 2017 Jan;18(1):123–131.

Published In

Expert Opin Pharmacother

DOI

EISSN

1744-7666

Publication Date

January 2017

Volume

18

Issue

1

Start / End Page

123 / 131

Location

England

Related Subject Headings

  • Secondary Prevention
  • Proton Pump Inhibitors
  • Platelet Aggregation Inhibitors
  • Pharmacology & Pharmacy
  • Omeprazole
  • Humans
  • Gastrointestinal Hemorrhage
  • Gastrointestinal Diseases
  • Coronary Artery Disease
  • Cardiovascular Diseases