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Toxicity and quality of life report of a phase II study of stereotactic body radiotherapy (SBRT) for low and intermediate risk prostate cancer.

Publication ,  Journal Article
Boyer, MJ; Papagikos, MA; Kiteley, R; Vujaskovic, Z; Wu, J; Lee, WR
Published in: Radiat Oncol
January 13, 2017

BACKGROUND: Clinical data indicates that delivery of larger daily doses of radiation may improve the therapeutic ratio for prostate cancer compared to conventional fractionation. A phase II study of stereotactic body radiotherapy with real-time motion management and daily plan re-optimization for low to intermediate risk prostate cancer was undertaken to evaluate this hypothesis. This report details the toxicity and quality of life following treatment. METHODS: From 2009 to 2013, 60 patients with T1-T2c prostate cancer with a Gleason score of 6 and PSA ≤ 15 or Gleason score of 7 and PSA ≤ 10 were enrolled. Patients with nodal metastases, an American Urological Association symptom score > 18, or gland size > 100 g were not eligible. Patients were treated to 37 Gy in 5 fractions. Early and late genitourinary and gastrointestinal toxicity were graded based on NCI CTCAE v4.0 and quality of life was assessed by the American Urological Association symptom score, International Index of Erectile Function, and Expanded Prostate cancer Index Composite Short Form up to 36 months after treatment. RESULTS: After a median follow-up of 27.6 months, no grade 3 or greater genitourinary toxicity was observed. Four patients (6.7%) reported a late grade 2 genitourinary toxicity. One patient (1.7%) reported a late grade 3 gastrointestinal toxicity. Five patients (8.3%) developed a late grade 2 gastrointestinal toxicity. The median American Urological Association symptom score increased from 4.5 prior to treatment to 11 while on treatment (p < 0.01), but was 5 at 36 months post-treatment (p = 0.65). Median International Index of Erectile Function scores decreased from 19 to 17 over the course of follow-up (p < 0.01). Only median scores within the Expanded Prostate Cancer Index Composite Short Form sexual domain were significantly decreased at 36 months post-treatment (67.9 vs 45.2, p = 0.02). There was no significant difference in median score within the urinary, bowel, or hormonal domains at 36 months of follow-up. CONCLUSIONS: Stereotactic body radiotherapy for low to intermediate risk prostate cancer is well tolerated with limited toxicity or decrease in quality of life. Longer follow-up is necessary to assess the efficacy of treatment. TRIAL REGISTRATION: Clinicaltrials.gov NCT00941915 Registered 17 June 2009.

Duke Scholars

Published In

Radiat Oncol

DOI

EISSN

1748-717X

Publication Date

January 13, 2017

Volume

12

Issue

1

Start / End Page

14

Location

England

Related Subject Headings

  • Radiotherapy Planning, Computer-Assisted
  • Radiosurgery
  • Quality of Life
  • Prostatic Neoplasms
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Aged, 80 and over
  • Aged
 

Citation

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Boyer, M. J., Papagikos, M. A., Kiteley, R., Vujaskovic, Z., Wu, J., & Lee, W. R. (2017). Toxicity and quality of life report of a phase II study of stereotactic body radiotherapy (SBRT) for low and intermediate risk prostate cancer. Radiat Oncol, 12(1), 14. https://doi.org/10.1186/s13014-016-0758-8
Boyer, Matthew J., Michael A. Papagikos, Rex Kiteley, Zeljko Vujaskovic, Jackie Wu, and W Robert Lee. “Toxicity and quality of life report of a phase II study of stereotactic body radiotherapy (SBRT) for low and intermediate risk prostate cancer.Radiat Oncol 12, no. 1 (January 13, 2017): 14. https://doi.org/10.1186/s13014-016-0758-8.
Boyer MJ, Papagikos MA, Kiteley R, Vujaskovic Z, Wu J, Lee WR. Toxicity and quality of life report of a phase II study of stereotactic body radiotherapy (SBRT) for low and intermediate risk prostate cancer. Radiat Oncol. 2017 Jan 13;12(1):14.
Boyer, Matthew J., et al. “Toxicity and quality of life report of a phase II study of stereotactic body radiotherapy (SBRT) for low and intermediate risk prostate cancer.Radiat Oncol, vol. 12, no. 1, Jan. 2017, p. 14. Pubmed, doi:10.1186/s13014-016-0758-8.
Boyer MJ, Papagikos MA, Kiteley R, Vujaskovic Z, Wu J, Lee WR. Toxicity and quality of life report of a phase II study of stereotactic body radiotherapy (SBRT) for low and intermediate risk prostate cancer. Radiat Oncol. 2017 Jan 13;12(1):14.
Journal cover image

Published In

Radiat Oncol

DOI

EISSN

1748-717X

Publication Date

January 13, 2017

Volume

12

Issue

1

Start / End Page

14

Location

England

Related Subject Headings

  • Radiotherapy Planning, Computer-Assisted
  • Radiosurgery
  • Quality of Life
  • Prostatic Neoplasms
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Aged, 80 and over
  • Aged