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Role of Piezo Channels in Joint Health and Injury.

Publication ,  Journal Article
Lee, W; Guilak, F; Liedtke, W
Published in: Curr Top Membr
2017

Cartilage is an intrinsically mechanically sensitive tissue composed of chondrocytes as the only cell type. Chondrocyte mechanotransduction is not well understood, but recently we identified critical components of the mechanotransduction machinery demonstrating how mechanical stimulation of these cells can be converted into cellular calcium signals. Physiologic mechanical cues induce anabolic responses of (post-mitotic) chondrocytes via transient receptor potential vanilloid 4 ion channels, whereas injurious mechanical stress is transduced by Piezo1 jointly with Piezo2 ion channels. This chapter sheds light on the latter discovery and provides a rationale for follow-up questions, such as the nature of interaction between Piezo1 and Piezo2, and their tethering to the cytoskeleton. These recent insights can be leveraged toward translational medical progress to benefit diagnosis and treatment of osteoarthritis, representing a large and growing unmet medical need in the United States and large parts of the world.

Duke Scholars

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Published In

Curr Top Membr

DOI

ISSN

1063-5823

Publication Date

2017

Volume

79

Start / End Page

263 / 273

Location

United States

Related Subject Headings

  • Stress, Mechanical
  • Mechanotransduction, Cellular
  • Joints
  • Ion Channels
  • Humans
  • Health
  • Chondrocytes
  • Biophysics
  • Animals
  • 3101 Biochemistry and cell biology
 

Citation

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Lee, W., Guilak, F., & Liedtke, W. (2017). Role of Piezo Channels in Joint Health and Injury. Curr Top Membr, 79, 263–273. https://doi.org/10.1016/bs.ctm.2016.10.003
Lee, W., F. Guilak, and W. Liedtke. “Role of Piezo Channels in Joint Health and Injury.Curr Top Membr 79 (2017): 263–73. https://doi.org/10.1016/bs.ctm.2016.10.003.
Lee W, Guilak F, Liedtke W. Role of Piezo Channels in Joint Health and Injury. Curr Top Membr. 2017;79:263–73.
Lee, W., et al. “Role of Piezo Channels in Joint Health and Injury.Curr Top Membr, vol. 79, 2017, pp. 263–73. Pubmed, doi:10.1016/bs.ctm.2016.10.003.
Lee W, Guilak F, Liedtke W. Role of Piezo Channels in Joint Health and Injury. Curr Top Membr. 2017;79:263–273.
Journal cover image

Published In

Curr Top Membr

DOI

ISSN

1063-5823

Publication Date

2017

Volume

79

Start / End Page

263 / 273

Location

United States

Related Subject Headings

  • Stress, Mechanical
  • Mechanotransduction, Cellular
  • Joints
  • Ion Channels
  • Humans
  • Health
  • Chondrocytes
  • Biophysics
  • Animals
  • 3101 Biochemistry and cell biology