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Complex immune correlates of protection in HIV-1 vaccine efficacy trials.

Publication ,  Journal Article
Tomaras, GD; Plotkin, SA
Published in: Immunol Rev
January 2017

Development of an efficacious HIV-1 vaccine is a major priority for improving human health worldwide. Vaccine-mediated protection against human pathogens can be achieved through elicitation of protective innate, humoral, and cellular responses. Identification of specific immune responses responsible for pathogen protection enables vaccine development and provides insights into host defenses against pathogens and the immunological mechanisms that most effectively fight infection. Defining immunological correlates of transmission risk in preclinical and clinical HIV-1 vaccine trials has moved the HIV-1 vaccine development field forward and directed new candidate vaccine development. Immune correlate studies are providing novel hypotheses about immunological mechanisms that may be responsible for preventing HIV-1 acquisition. Recent results from HIV-1 immune correlates work has demonstrated that there are multiple types of immune responses that together, comprise an immune correlate-thus implicating polyfunctional immune control of HIV-1 transmission. An in depth understanding of these complex immunological mechanisms of protection against HIV-1 will accelerate the development of an efficacious HIV-1 vaccine.

Duke Scholars

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Published In

Immunol Rev

DOI

EISSN

1600-065X

Publication Date

January 2017

Volume

275

Issue

1

Start / End Page

245 / 261

Location

England

Related Subject Headings

  • Risk
  • Immunology
  • Humans
  • HIV-1
  • HIV Infections
  • Disease Models, Animal
  • Clinical Trials as Topic
  • Animals
  • AIDS Vaccines
  • 3204 Immunology
 

Citation

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Tomaras, G. D., & Plotkin, S. A. (2017). Complex immune correlates of protection in HIV-1 vaccine efficacy trials. Immunol Rev, 275(1), 245–261. https://doi.org/10.1111/imr.12514
Tomaras, Georgia D., and Stanley A. Plotkin. “Complex immune correlates of protection in HIV-1 vaccine efficacy trials.Immunol Rev 275, no. 1 (January 2017): 245–61. https://doi.org/10.1111/imr.12514.
Tomaras GD, Plotkin SA. Complex immune correlates of protection in HIV-1 vaccine efficacy trials. Immunol Rev. 2017 Jan;275(1):245–61.
Tomaras, Georgia D., and Stanley A. Plotkin. “Complex immune correlates of protection in HIV-1 vaccine efficacy trials.Immunol Rev, vol. 275, no. 1, Jan. 2017, pp. 245–61. Pubmed, doi:10.1111/imr.12514.
Tomaras GD, Plotkin SA. Complex immune correlates of protection in HIV-1 vaccine efficacy trials. Immunol Rev. 2017 Jan;275(1):245–261.
Journal cover image

Published In

Immunol Rev

DOI

EISSN

1600-065X

Publication Date

January 2017

Volume

275

Issue

1

Start / End Page

245 / 261

Location

England

Related Subject Headings

  • Risk
  • Immunology
  • Humans
  • HIV-1
  • HIV Infections
  • Disease Models, Animal
  • Clinical Trials as Topic
  • Animals
  • AIDS Vaccines
  • 3204 Immunology