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A Model for HCMV Infection in Immunosuppressed Patients.

Publication ,  Journal Article
Kepler, GM; Banks, HT; Davidian, M; Rosenberg, ES
Published in: Math Comput Model
April 2009

We propose a model for HCMV infection in healthy and immunosuppressed patients. First, we present the biological model and formulate a system of ordinary differential equations to describe the pathogenesis of primary HCMV infection in immunocompetent and immunosuppressed individuals. We then investigate how clinical data can be applied to this model. Approximate parameter values for the model are derived from data available in the literature and from mathematical and physiological considerations. Simulations with the approximated parameter values demonstrates that the model is capable of describing primary, latent, and secondary (reactivated) HCMV infection. Reactivation simulations with this model provide a window into the dynamics of HCMV infection in (D-R+) transplant situations, where latently-infected recipients (R+) receive transplant tissue from HCMV-naive donors (D-).

Duke Scholars

Published In

Math Comput Model

DOI

ISSN

0895-7177

Publication Date

April 2009

Volume

49

Issue

7-8

Start / End Page

1653 / 1663

Location

England

Related Subject Headings

  • Numerical & Computational Mathematics
  • 4903 Numerical and computational mathematics
  • 4901 Applied mathematics
  • 4613 Theory of computation
  • 0802 Computation Theory and Mathematics
  • 0103 Numerical and Computational Mathematics
  • 0102 Applied Mathematics
 

Citation

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Kepler, G. M., Banks, H. T., Davidian, M., & Rosenberg, E. S. (2009). A Model for HCMV Infection in Immunosuppressed Patients. Math Comput Model, 49(7–8), 1653–1663. https://doi.org/10.1016/j.mcm.2008.06.003
Kepler, G. M., H. T. Banks, M. Davidian, and E. S. Rosenberg. “A Model for HCMV Infection in Immunosuppressed Patients.Math Comput Model 49, no. 7–8 (April 2009): 1653–63. https://doi.org/10.1016/j.mcm.2008.06.003.
Kepler GM, Banks HT, Davidian M, Rosenberg ES. A Model for HCMV Infection in Immunosuppressed Patients. Math Comput Model. 2009 Apr;49(7–8):1653–63.
Kepler, G. M., et al. “A Model for HCMV Infection in Immunosuppressed Patients.Math Comput Model, vol. 49, no. 7–8, Apr. 2009, pp. 1653–63. Pubmed, doi:10.1016/j.mcm.2008.06.003.
Kepler GM, Banks HT, Davidian M, Rosenberg ES. A Model for HCMV Infection in Immunosuppressed Patients. Math Comput Model. 2009 Apr;49(7–8):1653–1663.
Journal cover image

Published In

Math Comput Model

DOI

ISSN

0895-7177

Publication Date

April 2009

Volume

49

Issue

7-8

Start / End Page

1653 / 1663

Location

England

Related Subject Headings

  • Numerical & Computational Mathematics
  • 4903 Numerical and computational mathematics
  • 4901 Applied mathematics
  • 4613 Theory of computation
  • 0802 Computation Theory and Mathematics
  • 0103 Numerical and Computational Mathematics
  • 0102 Applied Mathematics