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An estimator for the proportional hazards model with multiple longitudinal covariates measured with error.

Publication ,  Journal Article
Song, X; Davidian, M; Tsiatis, AA
Published in: Biostatistics
December 2002

In many longitudinal studies, it is of interest to characterize the relationship between a time-to-event (e.g. survival) and several time-dependent and time-independent covariates. Time-dependent covariates are generally observed intermittently and with error. For a single time-dependent covariate, a popular approach is to assume a joint longitudinal data-survival model, where the time-dependent covariate follows a linear mixed effects model and the hazard of failure depends on random effects and time-independent covariates via a proportional hazards relationship. Regression calibration and likelihood or Bayesian methods have been advocated for implementation; however, generalization to more than one time-dependent covariate may become prohibitive. For a single time-dependent covariate, Tsiatis and Davidian (2001) have proposed an approach that is easily implemented and does not require an assumption on the distribution of the random effects. This technique may be generalized to multiple, possibly correlated, time-dependent covariates, as we demonstrate. We illustrate the approach via simulation and by application to data from an HIV clinical trial.

Duke Scholars

Published In

Biostatistics

DOI

ISSN

1465-4644

Publication Date

December 2002

Volume

3

Issue

4

Start / End Page

511 / 528

Location

England

Related Subject Headings

  • Statistics & Probability
  • 4905 Statistics
  • 0604 Genetics
  • 0104 Statistics
 

Citation

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Song, X., Davidian, M., & Tsiatis, A. A. (2002). An estimator for the proportional hazards model with multiple longitudinal covariates measured with error. Biostatistics, 3(4), 511–528. https://doi.org/10.1093/biostatistics/3.4.511
Song, Xiao, Marie Davidian, and Anastasios A. Tsiatis. “An estimator for the proportional hazards model with multiple longitudinal covariates measured with error.Biostatistics 3, no. 4 (December 2002): 511–28. https://doi.org/10.1093/biostatistics/3.4.511.
Song X, Davidian M, Tsiatis AA. An estimator for the proportional hazards model with multiple longitudinal covariates measured with error. Biostatistics. 2002 Dec;3(4):511–28.
Song, Xiao, et al. “An estimator for the proportional hazards model with multiple longitudinal covariates measured with error.Biostatistics, vol. 3, no. 4, Dec. 2002, pp. 511–28. Pubmed, doi:10.1093/biostatistics/3.4.511.
Song X, Davidian M, Tsiatis AA. An estimator for the proportional hazards model with multiple longitudinal covariates measured with error. Biostatistics. 2002 Dec;3(4):511–528.
Journal cover image

Published In

Biostatistics

DOI

ISSN

1465-4644

Publication Date

December 2002

Volume

3

Issue

4

Start / End Page

511 / 528

Location

England

Related Subject Headings

  • Statistics & Probability
  • 4905 Statistics
  • 0604 Genetics
  • 0104 Statistics