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Differences in viral dynamics between genotypes 1 and 2 of hepatitis C virus.

Publication ,  Journal Article
Neumann, AU; Lam, NP; Dahari, H; Davidian, M; Wiley, TE; Mika, BP; Perelson, AS; Layden, TJ
Published in: J Infect Dis
July 2000

Many studies have shown that patients infected with hepatitis C virus (HCV) of genotype 2 have better response to interferon (IFN)-alpha treatment than genotype 1 patients; however, the mechanisms responsible for this difference are not understood. In this study, viral dynamics during high-dose IFN induction treatment were compared between the genotypes. Patients in each group received 10 MU of IFN-alpha2b for 14 days, and HCV RNA levels were frequently determined. Nonlinear fitting, both individually for each patient and using a mixed-effects approach, of the viral kinetic data to a mathematical model of the IFN effect on HCV infection was performed. The antiviral effectiveness of IFN in blocking virus production, the free virion clearance rate, and the HCV-infected cell death rate were all significantly higher for genotype 2 patients than for genotype 1 patients. Thus, the better response rate of patients infected with HCV genotype 2 is multifactorial. This is the first finding of a difference in viral dynamics between subtypes of the same virus and demonstrates the importance of subtype-specific virus-host-drug interactions.

Duke Scholars

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

July 2000

Volume

182

Issue

1

Start / End Page

28 / 35

Location

United States

Related Subject Headings

  • RNA, Viral
  • Models, Theoretical
  • Middle Aged
  • Microbiology
  • Metabolic Clearance Rate
  • Male
  • Interferon-alpha
  • Humans
  • Hepatitis C
  • Hepacivirus
 

Citation

APA
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ICMJE
MLA
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Neumann, A. U., Lam, N. P., Dahari, H., Davidian, M., Wiley, T. E., Mika, B. P., … Layden, T. J. (2000). Differences in viral dynamics between genotypes 1 and 2 of hepatitis C virus. J Infect Dis, 182(1), 28–35. https://doi.org/10.1086/315661
Neumann, A. U., N. P. Lam, H. Dahari, M. Davidian, T. E. Wiley, B. P. Mika, A. S. Perelson, and T. J. Layden. “Differences in viral dynamics between genotypes 1 and 2 of hepatitis C virus.J Infect Dis 182, no. 1 (July 2000): 28–35. https://doi.org/10.1086/315661.
Neumann AU, Lam NP, Dahari H, Davidian M, Wiley TE, Mika BP, et al. Differences in viral dynamics between genotypes 1 and 2 of hepatitis C virus. J Infect Dis. 2000 Jul;182(1):28–35.
Neumann, A. U., et al. “Differences in viral dynamics between genotypes 1 and 2 of hepatitis C virus.J Infect Dis, vol. 182, no. 1, July 2000, pp. 28–35. Pubmed, doi:10.1086/315661.
Neumann AU, Lam NP, Dahari H, Davidian M, Wiley TE, Mika BP, Perelson AS, Layden TJ. Differences in viral dynamics between genotypes 1 and 2 of hepatitis C virus. J Infect Dis. 2000 Jul;182(1):28–35.
Journal cover image

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

July 2000

Volume

182

Issue

1

Start / End Page

28 / 35

Location

United States

Related Subject Headings

  • RNA, Viral
  • Models, Theoretical
  • Middle Aged
  • Microbiology
  • Metabolic Clearance Rate
  • Male
  • Interferon-alpha
  • Humans
  • Hepatitis C
  • Hepacivirus