Testing homogeneity of intra-run variance parameters in immunoassay.
Publication
, Journal Article
Zeng, Q; Davidian, M
Published in: Stat Med
August 15, 1997
A common assumption in the analysis of immunoassay data is a similar pattern of within-run variation across runs of the assays. One makes this assumption without formal investigation of its validity, despite the widely acknowledged fact that accurate understanding of intra-run variation is critical to reliable calibration inference. We propose a simple procedure for a formal test of the assumption of the homogeneity of parameters that characterize intra-run variation based on representation of standard curve data from multiple assay runs by a non-linear mixed effects model. We examine the performance of the procedure and investigate the robustness of calibration inference to incorrect assumptions about the pattern of intra-run variation.
Duke Scholars
Published In
Stat Med
DOI
ISSN
0277-6715
Publication Date
August 15, 1997
Volume
16
Issue
15
Start / End Page
1765 / 1776
Location
England
Related Subject Headings
- Statistics & Probability
- Sample Size
- Reproducibility of Results
- Random Allocation
- Nonlinear Dynamics
- Monte Carlo Method
- Models, Statistical
- Least-Squares Analysis
- Immunoassay
- Enzyme-Linked Immunosorbent Assay
Citation
APA
Chicago
ICMJE
MLA
NLM
Zeng, Q., & Davidian, M. (1997). Testing homogeneity of intra-run variance parameters in immunoassay. Stat Med, 16(15), 1765–1776. https://doi.org/10.1002/(sici)1097-0258(19970815)16:15<1765::aid-sim603>3.0.co;2-p
Zeng, Q., and M. Davidian. “Testing homogeneity of intra-run variance parameters in immunoassay.” Stat Med 16, no. 15 (August 15, 1997): 1765–76. https://doi.org/10.1002/(sici)1097-0258(19970815)16:15<1765::aid-sim603>3.0.co;2-p.
Zeng Q, Davidian M. Testing homogeneity of intra-run variance parameters in immunoassay. Stat Med. 1997 Aug 15;16(15):1765–76.
Zeng, Q., and M. Davidian. “Testing homogeneity of intra-run variance parameters in immunoassay.” Stat Med, vol. 16, no. 15, Aug. 1997, pp. 1765–76. Pubmed, doi:10.1002/(sici)1097-0258(19970815)16:15<1765::aid-sim603>3.0.co;2-p.
Zeng Q, Davidian M. Testing homogeneity of intra-run variance parameters in immunoassay. Stat Med. 1997 Aug 15;16(15):1765–1776.
Published In
Stat Med
DOI
ISSN
0277-6715
Publication Date
August 15, 1997
Volume
16
Issue
15
Start / End Page
1765 / 1776
Location
England
Related Subject Headings
- Statistics & Probability
- Sample Size
- Reproducibility of Results
- Random Allocation
- Nonlinear Dynamics
- Monte Carlo Method
- Models, Statistical
- Least-Squares Analysis
- Immunoassay
- Enzyme-Linked Immunosorbent Assay