Calibration inference based on multiple runs of an immunoassay.
Publication
, Journal Article
Zeng, Q; Davidian, M
Published in: Biometrics
December 1997
Several authors have documented the poor performance of usual large-sample, individual calibration confidence intervals based on a single run of an immunoassay. Inaccuracy of these intervals may be attributed to the paucity of information on model parameters available in a single run. Methods for combining information from multiple runs to estimate assay response variance parameters and to refine characterization of the standard curve for the current run via empirical Bayes techniques have been proposed. We investigate formally the utility of these techniques for improving the quality of routine individual calibration inference.
Duke Scholars
Published In
Biometrics
ISSN
0006-341X
Publication Date
December 1997
Volume
53
Issue
4
Start / End Page
1304 / 1317
Location
England
Related Subject Headings
- Statistics & Probability
- Recombinant Proteins
- Monte Carlo Method
- Models, Statistical
- Likelihood Functions
- Enzyme-Linked Immunosorbent Assay
- Deoxyribonucleases
- Computer Simulation
- Calibration
- Biometry
Citation
APA
Chicago
ICMJE
MLA
NLM
Zeng, Q., & Davidian, M. (1997). Calibration inference based on multiple runs of an immunoassay. Biometrics, 53(4), 1304–1317.
Zeng, Q., and M. Davidian. “Calibration inference based on multiple runs of an immunoassay.” Biometrics 53, no. 4 (December 1997): 1304–17.
Zeng Q, Davidian M. Calibration inference based on multiple runs of an immunoassay. Biometrics. 1997 Dec;53(4):1304–17.
Zeng, Q., and M. Davidian. “Calibration inference based on multiple runs of an immunoassay.” Biometrics, vol. 53, no. 4, Dec. 1997, pp. 1304–17.
Zeng Q, Davidian M. Calibration inference based on multiple runs of an immunoassay. Biometrics. 1997 Dec;53(4):1304–1317.
Published In
Biometrics
ISSN
0006-341X
Publication Date
December 1997
Volume
53
Issue
4
Start / End Page
1304 / 1317
Location
England
Related Subject Headings
- Statistics & Probability
- Recombinant Proteins
- Monte Carlo Method
- Models, Statistical
- Likelihood Functions
- Enzyme-Linked Immunosorbent Assay
- Deoxyribonucleases
- Computer Simulation
- Calibration
- Biometry