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Some general estimation methods for nonlinear mixed-effects models.

Publication ,  Journal Article
Davidian, M; Giltinan, DM
Published in: J Biopharm Stat
March 1993

A nonlinear mixed-effects model suitable for characterizing repeated measurement data is described. The model allows dependence of random coefficients on covariate information and accommodates general specifications of a common intraindividual covariance structure, such as models for variance within individuals that depend on individual mean response and autocorrelation. Two classes of procedures for estimation in this model are described, which incorporate estimation of unknown parameters in the assumed intraindividual covariance structure. The procedures are straightforward to implement using standard statistical software. The techniques are illustrated by examples in growth analysis and assay development.

Duke Scholars

Published In

J Biopharm Stat

DOI

ISSN

1054-3406

Publication Date

March 1993

Volume

3

Issue

1

Start / End Page

23 / 55

Location

England

Related Subject Headings

  • Statistics & Probability
  • Software
  • Relaxin
  • Models, Statistical
  • Models, Biological
  • Likelihood Functions
  • Least-Squares Analysis
  • Humans
  • Glycine max
  • Female
 

Citation

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Davidian, M., & Giltinan, D. M. (1993). Some general estimation methods for nonlinear mixed-effects models. J Biopharm Stat, 3(1), 23–55. https://doi.org/10.1080/10543409308835047
Davidian, M., and D. M. Giltinan. “Some general estimation methods for nonlinear mixed-effects models.J Biopharm Stat 3, no. 1 (March 1993): 23–55. https://doi.org/10.1080/10543409308835047.
Davidian M, Giltinan DM. Some general estimation methods for nonlinear mixed-effects models. J Biopharm Stat. 1993 Mar;3(1):23–55.
Davidian, M., and D. M. Giltinan. “Some general estimation methods for nonlinear mixed-effects models.J Biopharm Stat, vol. 3, no. 1, Mar. 1993, pp. 23–55. Pubmed, doi:10.1080/10543409308835047.
Davidian M, Giltinan DM. Some general estimation methods for nonlinear mixed-effects models. J Biopharm Stat. 1993 Mar;3(1):23–55.
Journal cover image

Published In

J Biopharm Stat

DOI

ISSN

1054-3406

Publication Date

March 1993

Volume

3

Issue

1

Start / End Page

23 / 55

Location

England

Related Subject Headings

  • Statistics & Probability
  • Software
  • Relaxin
  • Models, Statistical
  • Models, Biological
  • Likelihood Functions
  • Least-Squares Analysis
  • Humans
  • Glycine max
  • Female