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Progesterone receptors in the human heart and great vessels.

Publication ,  Journal Article
Ingegno, MD; Money, SR; Thelmo, W; Greene, GL; Davidian, M; Jaffe, BM; Pertschuk, LP
Published in: Lab Invest
September 1988

Progesterone receptors (PgR) were identified in 31 of 50 specimens of human (men and women) thoracic ascending aorta, internal carotid, coronary artery, and left atrial appendage. This was accomplished with a peroxidase-antiperoxidase immunocytochemical assay employing a highly specific monoclonal antibody to primate PgR. In the aorta, specific staining was seen in the nuclei of smooth muscle cells and endothelium of intima, media, and adventitia. In the myocardium, staining was localized to the nuclei of the myocardial fibers. In internal carotid and coronary arteries, PgR was localized to endothelial nuclei of intima, and in vascular channels within the atherosclerotic plaques. PgR was also visible in the smooth muscle cell nuclei of uninvolved media and intima and at the plaque periphery. In contrast, receptor was not identified in vessels of the human uterus, breast, prostate, kidney, or gastrointestinal tract. These findings suggest that the heart and great vessels are target organs for steroid hormones.

Duke Scholars

Published In

Lab Invest

ISSN

0023-6837

Publication Date

September 1988

Volume

59

Issue

3

Start / End Page

353 / 356

Location

United States

Related Subject Headings

  • Tissue Distribution
  • Receptors, Progesterone
  • Pathology
  • Myocardium
  • Middle Aged
  • Male
  • Immunohistochemistry
  • Humans
  • Female
  • Coronary Vessels
 

Citation

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Ingegno, M. D., Money, S. R., Thelmo, W., Greene, G. L., Davidian, M., Jaffe, B. M., & Pertschuk, L. P. (1988). Progesterone receptors in the human heart and great vessels. Lab Invest, 59(3), 353–356.
Ingegno, M. D., S. R. Money, W. Thelmo, G. L. Greene, M. Davidian, B. M. Jaffe, and L. P. Pertschuk. “Progesterone receptors in the human heart and great vessels.Lab Invest 59, no. 3 (September 1988): 353–56.
Ingegno MD, Money SR, Thelmo W, Greene GL, Davidian M, Jaffe BM, et al. Progesterone receptors in the human heart and great vessels. Lab Invest. 1988 Sep;59(3):353–6.
Ingegno, M. D., et al. “Progesterone receptors in the human heart and great vessels.Lab Invest, vol. 59, no. 3, Sept. 1988, pp. 353–56.
Ingegno MD, Money SR, Thelmo W, Greene GL, Davidian M, Jaffe BM, Pertschuk LP. Progesterone receptors in the human heart and great vessels. Lab Invest. 1988 Sep;59(3):353–356.

Published In

Lab Invest

ISSN

0023-6837

Publication Date

September 1988

Volume

59

Issue

3

Start / End Page

353 / 356

Location

United States

Related Subject Headings

  • Tissue Distribution
  • Receptors, Progesterone
  • Pathology
  • Myocardium
  • Middle Aged
  • Male
  • Immunohistochemistry
  • Humans
  • Female
  • Coronary Vessels