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A pilot study of mirtazapine in post-traumatic stress disorder.

Publication ,  Journal Article
Connor, KM; Davidson, JR; Weisler, RH; Ahearn, E
Published in: Int Clin Psychopharmacol
January 1999

Recently, studies of pharmacotherapy for post-traumatic stress disorder (PTSD) have been focused on serotonin-selective reuptake inhibitors (SSRI), despite a number of treatment-limiting side-effects. Mirtazapine, a novel drug with both noradrenergic and serotonergic properties, may be effective in individuals who demonstrate intolerance to side-effects of and a limited response to SSRIs. Six outpatients with severe, chronic PTSD were treated with mirtazapine, up to 45 mg/day for 8 weeks. Efficacy assessments and side-effect monitoring were performed at baseline and weeks 2, 4, 6 and 8. Fifty percent of the sample demonstrated improvement of 50% or more from baseline using a global rating. In addition, improvements were noted on both interviewer-administered and self-rated scales of PTSD and of depression. The drug was well tolerated with few significant side-effects. Mirtazapine was associated with clinical improvement in 50% of subjects with severe, chronic PTSD, suggesting a need for further investigation in double-blind, placebo-controlled trials.

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Published In

Int Clin Psychopharmacol

DOI

ISSN

0268-1315

Publication Date

January 1999

Volume

14

Issue

1

Start / End Page

29 / 31

Location

England

Related Subject Headings

  • Stress Disorders, Post-Traumatic
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Pilot Projects
  • Mirtazapine
  • Middle Aged
  • Mianserin
  • Male
  • Humans
  • Female
 

Citation

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Connor, K. M., Davidson, J. R., Weisler, R. H., & Ahearn, E. (1999). A pilot study of mirtazapine in post-traumatic stress disorder. Int Clin Psychopharmacol, 14(1), 29–31. https://doi.org/10.1097/00004850-199901000-00003
Connor, K. M., J. R. Davidson, R. H. Weisler, and E. Ahearn. “A pilot study of mirtazapine in post-traumatic stress disorder.Int Clin Psychopharmacol 14, no. 1 (January 1999): 29–31. https://doi.org/10.1097/00004850-199901000-00003.
Connor KM, Davidson JR, Weisler RH, Ahearn E. A pilot study of mirtazapine in post-traumatic stress disorder. Int Clin Psychopharmacol. 1999 Jan;14(1):29–31.
Connor, K. M., et al. “A pilot study of mirtazapine in post-traumatic stress disorder.Int Clin Psychopharmacol, vol. 14, no. 1, Jan. 1999, pp. 29–31. Pubmed, doi:10.1097/00004850-199901000-00003.
Connor KM, Davidson JR, Weisler RH, Ahearn E. A pilot study of mirtazapine in post-traumatic stress disorder. Int Clin Psychopharmacol. 1999 Jan;14(1):29–31.

Published In

Int Clin Psychopharmacol

DOI

ISSN

0268-1315

Publication Date

January 1999

Volume

14

Issue

1

Start / End Page

29 / 31

Location

England

Related Subject Headings

  • Stress Disorders, Post-Traumatic
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Pilot Projects
  • Mirtazapine
  • Middle Aged
  • Mianserin
  • Male
  • Humans
  • Female