Bupropion sustained release: a therapeutic overview.
Publication
, Journal Article
Davidson, JR; Connor, KM
Published in: J Clin Psychiatry
1998
Sustained-release bupropion (bupropion SR) represents a new form of an already known effective antidepressant drug. Its pharmacokinetics, mechanism of action, metabolism, and efficacy are reviewed. Benefit relative to placebo has been demonstrated in two large multicenter trials, with low doses (100 or 150 mg) having been shown to have therapeutic efficacy. An overview of all placebo-controlled trials of bupropion SR is given, and the differential properties of bupropion and serotonergic drugs are described. The concept of a catecholamine-indolamine spectrum is presented, along with its implications for possible differential therapeutics of selective antidepressants.
Duke Scholars
Published In
J Clin Psychiatry
ISSN
0160-6689
Publication Date
1998
Volume
59 Suppl 4
Start / End Page
25 / 31
Location
United States
Related Subject Headings
- Treatment Outcome
- Sertraline
- Serotonin Agents
- Psychiatry
- Placebos
- Humans
- Drug Administration Schedule
- Depressive Disorder
- Delayed-Action Preparations
- Clinical Trials as Topic
Citation
APA
Chicago
ICMJE
MLA
NLM
Davidson, J. R., & Connor, K. M. (1998). Bupropion sustained release: a therapeutic overview. J Clin Psychiatry, 59 Suppl 4, 25–31.
Davidson, J. R., and K. M. Connor. “Bupropion sustained release: a therapeutic overview.” J Clin Psychiatry 59 Suppl 4 (1998): 25–31.
Davidson JR, Connor KM. Bupropion sustained release: a therapeutic overview. J Clin Psychiatry. 1998;59 Suppl 4:25–31.
Davidson, J. R., and K. M. Connor. “Bupropion sustained release: a therapeutic overview.” J Clin Psychiatry, vol. 59 Suppl 4, 1998, pp. 25–31.
Davidson JR, Connor KM. Bupropion sustained release: a therapeutic overview. J Clin Psychiatry. 1998;59 Suppl 4:25–31.
Published In
J Clin Psychiatry
ISSN
0160-6689
Publication Date
1998
Volume
59 Suppl 4
Start / End Page
25 / 31
Location
United States
Related Subject Headings
- Treatment Outcome
- Sertraline
- Serotonin Agents
- Psychiatry
- Placebos
- Humans
- Drug Administration Schedule
- Depressive Disorder
- Delayed-Action Preparations
- Clinical Trials as Topic