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Effects of acetaminophen and nonsteroidal anti-inflammatory drugs on progesterone production by porcine granulosa cells in vitro.

Publication ,  Journal Article
Haney, AF; Hughes, SF; Hughes, CL
Published in: Reprod Toxicol
1987

We investigated the effects of a group of pharmaceutical agents commonly ingested by reproductive-aged women, acetaminophen and the nonsteroidal anti-inflammatory drugs (NSAID), on progesterone (P) production by cultures of highly differentiated porcine granulosa cells. These compounds were added to cultures over a dose range of 10(-8) to 10(-5) M and P, and cell protein was measured after 24 hours. P production was suppressed by acetaminophen, fenoprofen, and sulindac to a maximum of 81%, 76%, and 71% of control, respectively. P production was enhanced by butazolidin at all doses tested to a maximum of 140% of control. Granulosa cell protein was suppressed by butazolidin and salicylic acid to a maximum of 81% of controls. These data imply that acetaminophen and several NSAID have the potential for clinical reproductive toxicity with differing individual effects on reproductive tract tissues, suggesting further selective testing in vivo.

Duke Scholars

Published In

Reprod Toxicol

DOI

ISSN

0890-6238

Publication Date

1987

Volume

1

Issue

4

Start / End Page

285 / 291

Location

United States

Related Subject Headings

  • Toxicology
  • Swine
  • Progesterone
  • Granulosa Cells
  • Female
  • Cryopreservation
  • Cells, Cultured
  • Anti-Inflammatory Agents, Non-Steroidal
  • Animals
  • Analysis of Variance
 

Citation

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Haney, A. F., Hughes, S. F., & Hughes, C. L. (1987). Effects of acetaminophen and nonsteroidal anti-inflammatory drugs on progesterone production by porcine granulosa cells in vitro. Reprod Toxicol, 1(4), 285–291. https://doi.org/10.1016/0890-6238(87)90020-7
Haney, A. F., S. F. Hughes, and C. L. Hughes. “Effects of acetaminophen and nonsteroidal anti-inflammatory drugs on progesterone production by porcine granulosa cells in vitro.Reprod Toxicol 1, no. 4 (1987): 285–91. https://doi.org/10.1016/0890-6238(87)90020-7.
Haney, A. F., et al. “Effects of acetaminophen and nonsteroidal anti-inflammatory drugs on progesterone production by porcine granulosa cells in vitro.Reprod Toxicol, vol. 1, no. 4, 1987, pp. 285–91. Pubmed, doi:10.1016/0890-6238(87)90020-7.
Journal cover image

Published In

Reprod Toxicol

DOI

ISSN

0890-6238

Publication Date

1987

Volume

1

Issue

4

Start / End Page

285 / 291

Location

United States

Related Subject Headings

  • Toxicology
  • Swine
  • Progesterone
  • Granulosa Cells
  • Female
  • Cryopreservation
  • Cells, Cultured
  • Anti-Inflammatory Agents, Non-Steroidal
  • Animals
  • Analysis of Variance