Skip to main content
Journal cover image

Assessment of Structural Heterogeneity and Viscosity in the Cervix Using Shear Wave Elasticity Imaging: Initial Results from a Rhesus Macaque Model.

Publication ,  Journal Article
Rosado-Mendez, IM; Palmeri, ML; Drehfal, LC; Guerrero, QW; Simmons, H; Feltovich, H; Hall, TJ
Published in: Ultrasound in medicine & biology
April 2017

Shear wave elasticity imaging has shown promise in evaluation of the pregnant cervix. Changes in shear wave group velocity have been attributed exclusively to changes in stiffness. This assumes homogeneity within the region of interest and purely elastic tissue behavior. However, the cervix is structurally/microstructurally heterogeneous and viscoelastic. We therefore developed strategies to investigate these complex tissue properties. Shear wave elasticity imaging was performed ex vivo on 14 unripened and 13 misoprostol-ripened cervix specimens from rhesus macaques. After tests of significant and uniform shear wave displacement, as well as reliability of estimates, group velocity decreased significantly from the distal (vaginal) to proximal (uterine) end of unripened, but not ripened, specimens. Viscosity was quantified by the slope of the phase velocity versus frequency. Dispersion was observed in both groups (median: 5.5 m/s/kHz, interquartile range: 1.5-12.0 m/s/kHz), also decreasing toward the proximal cervix. This work suggests that comprehensive assessment of complex tissues such as cervix requires consideration of structural heterogeneity and viscosity.

Duke Scholars

Published In

Ultrasound in medicine & biology

DOI

EISSN

1879-291X

ISSN

0301-5629

Publication Date

April 2017

Volume

43

Issue

4

Start / End Page

790 / 803

Related Subject Headings

  • Viscosity
  • Reproducibility of Results
  • Models, Animal
  • Macaca mulatta
  • Female
  • Elasticity Imaging Techniques
  • Cervix Uteri
  • Animals
  • Acoustics
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rosado-Mendez, I. M., Palmeri, M. L., Drehfal, L. C., Guerrero, Q. W., Simmons, H., Feltovich, H., & Hall, T. J. (2017). Assessment of Structural Heterogeneity and Viscosity in the Cervix Using Shear Wave Elasticity Imaging: Initial Results from a Rhesus Macaque Model. Ultrasound in Medicine & Biology, 43(4), 790–803. https://doi.org/10.1016/j.ultrasmedbio.2016.12.006
Rosado-Mendez, Ivan M., Mark L. Palmeri, Lindsey C. Drehfal, Quinton W. Guerrero, Heather Simmons, Helen Feltovich, and Timothy J. Hall. “Assessment of Structural Heterogeneity and Viscosity in the Cervix Using Shear Wave Elasticity Imaging: Initial Results from a Rhesus Macaque Model.Ultrasound in Medicine & Biology 43, no. 4 (April 2017): 790–803. https://doi.org/10.1016/j.ultrasmedbio.2016.12.006.
Rosado-Mendez IM, Palmeri ML, Drehfal LC, Guerrero QW, Simmons H, Feltovich H, et al. Assessment of Structural Heterogeneity and Viscosity in the Cervix Using Shear Wave Elasticity Imaging: Initial Results from a Rhesus Macaque Model. Ultrasound in medicine & biology. 2017 Apr;43(4):790–803.
Rosado-Mendez, Ivan M., et al. “Assessment of Structural Heterogeneity and Viscosity in the Cervix Using Shear Wave Elasticity Imaging: Initial Results from a Rhesus Macaque Model.Ultrasound in Medicine & Biology, vol. 43, no. 4, Apr. 2017, pp. 790–803. Epmc, doi:10.1016/j.ultrasmedbio.2016.12.006.
Rosado-Mendez IM, Palmeri ML, Drehfal LC, Guerrero QW, Simmons H, Feltovich H, Hall TJ. Assessment of Structural Heterogeneity and Viscosity in the Cervix Using Shear Wave Elasticity Imaging: Initial Results from a Rhesus Macaque Model. Ultrasound in medicine & biology. 2017 Apr;43(4):790–803.
Journal cover image

Published In

Ultrasound in medicine & biology

DOI

EISSN

1879-291X

ISSN

0301-5629

Publication Date

April 2017

Volume

43

Issue

4

Start / End Page

790 / 803

Related Subject Headings

  • Viscosity
  • Reproducibility of Results
  • Models, Animal
  • Macaca mulatta
  • Female
  • Elasticity Imaging Techniques
  • Cervix Uteri
  • Animals
  • Acoustics
  • 3202 Clinical sciences