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Associations of gender and a proxy of female menopausal status with histological features of drug-induced liver injury.

Publication ,  Journal Article
Suzuki, A; Barnhart, H; Gu, J; Bonkovsky, HL; Tillmann, HL; Fontana, RJ; Kleiner, DE; Drug-induced Liver Injury Network (DILIN),
Published in: Liver Int
November 2017

BACKGROUND & AIM: Gender and menopause may contribute to type and severity of drug-induced liver injury (DILI) by influencing host responses to injury. The aim of this study was to assess the associations of gender and female age 50 [a proxy of menopause] with histological features of liver injury in 212 adults enrolled in the Drug-Induced Liver Injury Network (DILIN) registry. METHODS: All participants had a causality score of at least 'probable', a liver biopsy within 30 days of DILI onset, and no prior chronic liver disease. Biochemical and histological injury types were classified as hepatocellular or cholestatic/mixed injury. The cohort was divided into three gender/age categories: men (41.0%), women <50 years (27.4%) and women ≥50 years of age (31.6%). Interaction of gender and age category (≥50 or not) was assessed. RESULTS: Hepatocellular injury was more prevalent in women <50 years vs. others (P=.002). After adjusting for biochemical injury types, black race and possible ageing effects, more severe interface hepatitis was noted in biopsies of women <50 years compared to those of men and women ≥50 years (P=.009 and P=.055 respectively). Compared to those of men, biopsies of women showed greater plasma cell infiltration, hepatocyte apoptosis, hepatocyte rosettes and lobular disarray but less iron-positive hepatocytes and histological cholestasis (P<.05). These associations persisted after excluding cases of amoxicillin/clavulanic acid, anabolic steroids or nitrofurantoin DILI which showed gender-specific distributions. CONCLUSION: Gender and a proxy of menopause were associated with various features of inflammation and injury in DILI.

Duke Scholars

Published In

Liver Int

DOI

EISSN

1478-3231

Publication Date

November 2017

Volume

37

Issue

11

Start / End Page

1723 / 1730

Location

United States

Related Subject Headings

  • Sex Factors
  • Middle Aged
  • Menopause
  • Male
  • Logistic Models
  • Humans
  • Gastroenterology & Hepatology
  • Female
  • Cross-Sectional Studies
  • Cohort Studies
 

Citation

APA
Chicago
ICMJE
MLA
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Suzuki, A., Barnhart, H., Gu, J., Bonkovsky, H. L., Tillmann, H. L., Fontana, R. J., … Drug-induced Liver Injury Network (DILIN), . (2017). Associations of gender and a proxy of female menopausal status with histological features of drug-induced liver injury. Liver Int, 37(11), 1723–1730. https://doi.org/10.1111/liv.13380
Suzuki, Ayako, Huiman Barnhart, Jiezhun Gu, Herbert L. Bonkovsky, Hans L. Tillmann, Robert J. Fontana, David E. Kleiner, and David E. Drug-induced Liver Injury Network (DILIN). “Associations of gender and a proxy of female menopausal status with histological features of drug-induced liver injury.Liver Int 37, no. 11 (November 2017): 1723–30. https://doi.org/10.1111/liv.13380.
Suzuki A, Barnhart H, Gu J, Bonkovsky HL, Tillmann HL, Fontana RJ, et al. Associations of gender and a proxy of female menopausal status with histological features of drug-induced liver injury. Liver Int. 2017 Nov;37(11):1723–30.
Suzuki, Ayako, et al. “Associations of gender and a proxy of female menopausal status with histological features of drug-induced liver injury.Liver Int, vol. 37, no. 11, Nov. 2017, pp. 1723–30. Pubmed, doi:10.1111/liv.13380.
Suzuki A, Barnhart H, Gu J, Bonkovsky HL, Tillmann HL, Fontana RJ, Kleiner DE, Drug-induced Liver Injury Network (DILIN). Associations of gender and a proxy of female menopausal status with histological features of drug-induced liver injury. Liver Int. 2017 Nov;37(11):1723–1730.
Journal cover image

Published In

Liver Int

DOI

EISSN

1478-3231

Publication Date

November 2017

Volume

37

Issue

11

Start / End Page

1723 / 1730

Location

United States

Related Subject Headings

  • Sex Factors
  • Middle Aged
  • Menopause
  • Male
  • Logistic Models
  • Humans
  • Gastroenterology & Hepatology
  • Female
  • Cross-Sectional Studies
  • Cohort Studies