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Polypoidal Choroidal Vasculopathy in Asians.

Publication ,  Journal Article
Wong, CW; Wong, TY; Cheung, CMG
Published in: Journal of clinical medicine
April 2015

Age related macular degeneration (AMD) in Asians has been suggested to differ from their Western counterparts in terms of epidemiology, pathogenesis, clinical presentation and treatment. In particular, polypoidal choroidal vasculopathy (PCV) appears to be the predominant subtype of exudative AMD in Asian populations, in contrast to choroidal neovascularization secondary to AMD (CNV-AMD) in Western populations. Epidemiological data on PCV has been largely limited to hospital-based studies and there are currently no data on the incidence of PCV. Similarities and differences in risk factor profile between PCV and CNV-AMD point to some shared pathogenic mechanisms but also differential underlying mechanisms leading to the development of each phenotype. Serum biomarkers such as CRP, homocysteine and matrix metalloproteinases suggest underlying inflammation, atherosclerosis and deranged extracellular matrix metabolism as possible pathogenic mechanisms. In addition, recent advances in genome sequencing have revealed differences in genetic determinants of each subtype. While the standard of care for CNV-AMD is anti-vascular endothelial growth factor (VEGF) therapy, photodynamic therapy (PDT) has been the mainstay of treatment for PCV, although long-term visual prognosis remains unsatisfactory. The optimal treatment for PCV requires further clarification, particularly with different types of anti-VEGF agents and possible benefits of reduced fluence PDT.

Published In

Journal of clinical medicine

DOI

EISSN

2077-0383

ISSN

2077-0383

Publication Date

April 2015

Volume

4

Issue

5

Start / End Page

782 / 821

Related Subject Headings

  • 32 Biomedical and clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wong, C. W., Wong, T. Y., & Cheung, C. M. G. (2015). Polypoidal Choroidal Vasculopathy in Asians. Journal of Clinical Medicine, 4(5), 782–821. https://doi.org/10.3390/jcm4050782
Wong, Chee Wai, Tien Y. Wong, and Chui Ming Gemmy Cheung. “Polypoidal Choroidal Vasculopathy in Asians.Journal of Clinical Medicine 4, no. 5 (April 2015): 782–821. https://doi.org/10.3390/jcm4050782.
Wong CW, Wong TY, Cheung CMG. Polypoidal Choroidal Vasculopathy in Asians. Journal of clinical medicine. 2015 Apr;4(5):782–821.
Wong, Chee Wai, et al. “Polypoidal Choroidal Vasculopathy in Asians.Journal of Clinical Medicine, vol. 4, no. 5, Apr. 2015, pp. 782–821. Epmc, doi:10.3390/jcm4050782.
Wong CW, Wong TY, Cheung CMG. Polypoidal Choroidal Vasculopathy in Asians. Journal of clinical medicine. 2015 Apr;4(5):782–821.

Published In

Journal of clinical medicine

DOI

EISSN

2077-0383

ISSN

2077-0383

Publication Date

April 2015

Volume

4

Issue

5

Start / End Page

782 / 821

Related Subject Headings

  • 32 Biomedical and clinical sciences
  • 1103 Clinical Sciences