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Ovarian cancer epidemiology in the era of collaborative team science.

Publication ,  Journal Article
Cannioto, RA; Trabert, B; Poole, EM; Schildkraut, JM
Published in: Cancer Causes Control
May 2017

PURPOSE: Over the past decade, a number of consortia have formed to further investigate genetic associations, pathogenesis, and epidemiologic risk and prognostic factors for ovarian cancer. Here, we review the benefits that ovarian cancer consortia provide as well as challenges that have arisen. Methods for managing key challenges are also discussed. METHODS: We review the structural organization and some of the milestone epidemiologic publications of five consortia dedicated to the study of ovarian cancer, including the Ovarian Cancer Association Consortium (OCAC), the Ovarian Tumor Tissue Analysis (OTTA) Consortium, the Ovarian Cancer Cohort Consortium (OC3), the Collaborative Group on Epidemiological Studies of Ovarian Cancer (The Oxford Collaborative Group), and the Ovarian Cancer in Women of African Ancestry (OCWAA) consortium. RESULTS: As ovarian cancer is a rare and heterogeneous disease, consortia have made important contributions in the study of risk factors by improving statistical power beyond what any single study, or even a few studies, would provide. Thus, a major accomplishment of consortial research is enhanced characterization of histotype-specific risk factor associations. In addition, consortia have facilitated impressive synergy between researchers across many institutions, spawning new collaborative research. Importantly, through these efforts, many challenges have been met, including difficulties with data harmonization and analysis, laying a road map for future collaborations. CONCLUSIONS: While ovarian cancer consortia have made valuable contributions to the ovarian cancer epidemiological literature over the past decade, additional efforts comprising of new, well-designed case-control studies are needed to further elucidate novel, histotype-specific risk, and prognostic factors which are not consistently available in existing studies.

Duke Scholars

Published In

Cancer Causes Control

DOI

EISSN

1573-7225

Publication Date

May 2017

Volume

28

Issue

5

Start / End Page

487 / 495

Location

Netherlands

Related Subject Headings

  • Risk Factors
  • Research Design
  • Ovarian Neoplasms
  • Humans
  • Female
  • Epidemiology
  • Cooperative Behavior
  • Case-Control Studies
  • 4202 Epidemiology
  • 3211 Oncology and carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
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Cannioto, R. A., Trabert, B., Poole, E. M., & Schildkraut, J. M. (2017). Ovarian cancer epidemiology in the era of collaborative team science. Cancer Causes Control, 28(5), 487–495. https://doi.org/10.1007/s10552-017-0862-6
Cannioto, Rikki A., Britton Trabert, Elizabeth M. Poole, and Joellen M. Schildkraut. “Ovarian cancer epidemiology in the era of collaborative team science.Cancer Causes Control 28, no. 5 (May 2017): 487–95. https://doi.org/10.1007/s10552-017-0862-6.
Cannioto RA, Trabert B, Poole EM, Schildkraut JM. Ovarian cancer epidemiology in the era of collaborative team science. Cancer Causes Control. 2017 May;28(5):487–95.
Cannioto, Rikki A., et al. “Ovarian cancer epidemiology in the era of collaborative team science.Cancer Causes Control, vol. 28, no. 5, May 2017, pp. 487–95. Pubmed, doi:10.1007/s10552-017-0862-6.
Cannioto RA, Trabert B, Poole EM, Schildkraut JM. Ovarian cancer epidemiology in the era of collaborative team science. Cancer Causes Control. 2017 May;28(5):487–495.
Journal cover image

Published In

Cancer Causes Control

DOI

EISSN

1573-7225

Publication Date

May 2017

Volume

28

Issue

5

Start / End Page

487 / 495

Location

Netherlands

Related Subject Headings

  • Risk Factors
  • Research Design
  • Ovarian Neoplasms
  • Humans
  • Female
  • Epidemiology
  • Cooperative Behavior
  • Case-Control Studies
  • 4202 Epidemiology
  • 3211 Oncology and carcinogenesis