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Moving messages in the developing brain-emerging roles for mRNA transport and local translation in neural stem cells.

Publication ,  Journal Article
Pilaz, L-J; Silver, DL
Published in: FEBS Lett
June 2017

The mammalian cerebral cortex is a complex brain structure integral to our higher cognition. During embryonic cortical development, radial glial progenitors (RGCs) produce neurons and serve as physical structures for migrating neurons. Recent discoveries highlight new roles for RNA localization and local translation in RGCs, both at the cell body and at distal structures called basal endfeet. By implementing technologies from the field of RNA research to brain development, investigators can manipulate RNA-binding proteins as well as visualize single-molecule RNAs, live movement of mRNAs and their binding proteins, and translation. Going forward, these studies establish a framework for investigating how post-transcriptional RNA regulation helps shape RGC function and triggers neurodevelopmental diseases.

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Published In

FEBS Lett

DOI

EISSN

1873-3468

Publication Date

June 2017

Volume

591

Issue

11

Start / End Page

1526 / 1539

Location

England

Related Subject Headings

  • RNA-Binding Proteins
  • RNA, Messenger
  • RNA Transport
  • Neural Stem Cells
  • Models, Biological
  • Humans
  • Ependymoglial Cells
  • Brain
  • Biochemistry & Molecular Biology
  • Animals
 

Citation

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Pilaz, L.-J., & Silver, D. L. (2017). Moving messages in the developing brain-emerging roles for mRNA transport and local translation in neural stem cells. FEBS Lett, 591(11), 1526–1539. https://doi.org/10.1002/1873-3468.12626
Pilaz, Louis-Jan, and Debra L. Silver. “Moving messages in the developing brain-emerging roles for mRNA transport and local translation in neural stem cells.FEBS Lett 591, no. 11 (June 2017): 1526–39. https://doi.org/10.1002/1873-3468.12626.
Pilaz, Louis-Jan, and Debra L. Silver. “Moving messages in the developing brain-emerging roles for mRNA transport and local translation in neural stem cells.FEBS Lett, vol. 591, no. 11, June 2017, pp. 1526–39. Pubmed, doi:10.1002/1873-3468.12626.
Journal cover image

Published In

FEBS Lett

DOI

EISSN

1873-3468

Publication Date

June 2017

Volume

591

Issue

11

Start / End Page

1526 / 1539

Location

England

Related Subject Headings

  • RNA-Binding Proteins
  • RNA, Messenger
  • RNA Transport
  • Neural Stem Cells
  • Models, Biological
  • Humans
  • Ependymoglial Cells
  • Brain
  • Biochemistry & Molecular Biology
  • Animals