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Hospitalization rates among survivors of childhood cancer in the Childhood Cancer Survivor Study cohort.

Publication ,  Journal Article
Kurt, BA; Nolan, VG; Ness, KK; Neglia, JP; Tersak, JM; Hudson, MM; Armstrong, GT; Hutchinson, RJ; Leisenring, WM; Oeffinger, KC; Robison, LL; Arora, M
Published in: Pediatr Blood Cancer
July 15, 2012

BACKGROUND: Chronic health conditions are common among long-term childhood cancer survivors, but hospitalization rates have not been reported. The objective of this study was to determine overall and cause-specific hospitalization rates among survivors of childhood cancer and compare rates to the U.S. population. PROCEDURE: The Childhood Cancer Survivor Study (CCSS) is a retrospective cohort of 5+ year survivors of childhood malignancies treated at 26 participating centers. Self-reported hospitalizations from 10,366 survivors (diagnosed 1970-1986) were compared to U.S. population rates using age- and sex-stratified standardized incidence ratios (SIRs). Reasons for hospitalization were evaluated and associations between demographic, cancer and treatment-related risk factors with hospitalization were investigated. RESULTS: Survivors were, on average, 20.9 years from cancer diagnosis (SD: 4.6, range: 13-32) and 28.6 years of age (SD: 7.7, range: 13-51). Survivor hospitalization rates were 1.6 times the U.S. population (95% CI: 1.6; 1.7). Increased hospitalization rates were noted irrespective of gender, age at follow-up and cancer diagnosis, with highest SIRs noted among male (SIR = 2.6, 95% CI: 2.2; 3.0) and female (SIR = 2.7, 95% CI: 2.4; 3.1) survivors aged 45-54. Female gender, an existing chronic health condition and/or a second neoplasm, and prior treatment with radiation were associated with an increased risk of non-obstetrical hospitalization. CONCLUSIONS: Survivors of childhood cancer demonstrate substantially higher hospitalization rates. Additional research is needed to further quantify the healthcare utilization and economic impact of treatment-related complications as this population ages.

Duke Scholars

Published In

Pediatr Blood Cancer

DOI

EISSN

1545-5017

Publication Date

July 15, 2012

Volume

59

Issue

1

Start / End Page

126 / 132

Location

United States

Related Subject Headings

  • United States
  • Time Factors
  • Survivors
  • Sex Factors
  • Retrospective Studies
  • Oncology & Carcinogenesis
  • Neoplasms
  • Middle Aged
  • Male
  • Incidence
 

Citation

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Kurt, B. A., Nolan, V. G., Ness, K. K., Neglia, J. P., Tersak, J. M., Hudson, M. M., … Arora, M. (2012). Hospitalization rates among survivors of childhood cancer in the Childhood Cancer Survivor Study cohort. Pediatr Blood Cancer, 59(1), 126–132. https://doi.org/10.1002/pbc.24017
Kurt, Beth A., Vikki G. Nolan, Kirsten K. Ness, Joseph P. Neglia, Jean M. Tersak, Melissa M. Hudson, Gregory T. Armstrong, et al. “Hospitalization rates among survivors of childhood cancer in the Childhood Cancer Survivor Study cohort.Pediatr Blood Cancer 59, no. 1 (July 15, 2012): 126–32. https://doi.org/10.1002/pbc.24017.
Kurt BA, Nolan VG, Ness KK, Neglia JP, Tersak JM, Hudson MM, et al. Hospitalization rates among survivors of childhood cancer in the Childhood Cancer Survivor Study cohort. Pediatr Blood Cancer. 2012 Jul 15;59(1):126–32.
Kurt, Beth A., et al. “Hospitalization rates among survivors of childhood cancer in the Childhood Cancer Survivor Study cohort.Pediatr Blood Cancer, vol. 59, no. 1, July 2012, pp. 126–32. Pubmed, doi:10.1002/pbc.24017.
Kurt BA, Nolan VG, Ness KK, Neglia JP, Tersak JM, Hudson MM, Armstrong GT, Hutchinson RJ, Leisenring WM, Oeffinger KC, Robison LL, Arora M. Hospitalization rates among survivors of childhood cancer in the Childhood Cancer Survivor Study cohort. Pediatr Blood Cancer. 2012 Jul 15;59(1):126–132.
Journal cover image

Published In

Pediatr Blood Cancer

DOI

EISSN

1545-5017

Publication Date

July 15, 2012

Volume

59

Issue

1

Start / End Page

126 / 132

Location

United States

Related Subject Headings

  • United States
  • Time Factors
  • Survivors
  • Sex Factors
  • Retrospective Studies
  • Oncology & Carcinogenesis
  • Neoplasms
  • Middle Aged
  • Male
  • Incidence