Skip to main content
Journal cover image

Health status of adult long-term survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.

Publication ,  Journal Article
Hudson, MM; Mertens, AC; Yasui, Y; Hobbie, W; Chen, H; Gurney, JG; Yeazel, M; Recklitis, CJ; Marina, N; Robison, LR; Oeffinger, KC ...
Published in: JAMA
September 24, 2003

CONTEXT: Adult survivors of childhood cancer are at risk for medical and psychosocial sequelae that may adversely affect their health status. OBJECTIVES: To compare the health status of adult survivors of childhood cancer and siblings and to identify factors associated with adverse outcomes. DESIGN, SETTING, AND PARTICIPANTS: Health status was assessed in 9535 adult participants of the Childhood Cancer Survivor Study, a cohort of long-term survivors of childhood cancer who were diagnosed between 1970 and 1986. A randomly selected cohort of the survivors' siblings (n = 2916) served as a comparison group. MAIN OUTCOME MEASURES: Six health status domains were assessed: general health, mental health, functional status, activity limitations, cancer-related pain, and cancer-related anxiety/fears. The first 4 domains were assessed in the control group. RESULTS: Survivors were significantly more likely to report adverse general health (odds ratio [OR], 2.5; 95% confidence interval [CI], 2.1-3.0; P<.001), mental health (OR, 1.8; 95% CI, 1.6-2.1; P<.001), activity limitations (OR, 2.7; 95% CI, 2.3-3.3; P<.001), and functional impairment (OR, 5.2; 95% CI, 4.1-6.6; P<.001), compared with siblings. Forty-four percent of survivors reported at least 1 adversely affected health status domain. Sociodemographic factors associated with reporting at least 1 adverse health status domain included being female (OR, 1.4; 95% CI, 1.3-1.6; P<.001), lower level of educational attainment (OR, 2.0; 95% CI, 1.8-2.2; P<.001), and annual income less than 20 000 dollars (OR, 1.8; 95% CI, 1.6-2.1; P<.001). Relative to those survivors with childhood leukemia, an increased risk was observed for at least 1 adverse health status domain among those with bone tumors (OR, 2.1; 95% CI, 1.8-2.5; P<.001), central nervous system tumors (OR, 1.7; 95% CI, 1.5-2.0; P<.001), and sarcomas (OR, 1.2; 95% CI, 1.1-1.5; P =.01). CONCLUSION: Clinicians caring for adult survivors of childhood cancer should be aware of the substantial risk for adverse health status, especially among females, those with low educational attainment, and those with low household incomes.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

JAMA

DOI

EISSN

1538-3598

Publication Date

September 24, 2003

Volume

290

Issue

12

Start / End Page

1583 / 1592

Location

United States

Related Subject Headings

  • Survivors
  • Socioeconomic Factors
  • Siblings
  • Regression Analysis
  • Neoplasms
  • Middle Aged
  • Male
  • Infant
  • Humans
  • Health Surveys
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hudson, M. M., Mertens, A. C., Yasui, Y., Hobbie, W., Chen, H., Gurney, J. G., … Childhood Cancer Survivor Study Investigators, . (2003). Health status of adult long-term survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. JAMA, 290(12), 1583–1592. https://doi.org/10.1001/jama.290.12.1583
Hudson, Melissa M., Ann C. Mertens, Yutaka Yasui, Wendy Hobbie, Hegang Chen, James G. Gurney, Mark Yeazel, et al. “Health status of adult long-term survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.JAMA 290, no. 12 (September 24, 2003): 1583–92. https://doi.org/10.1001/jama.290.12.1583.
Hudson MM, Mertens AC, Yasui Y, Hobbie W, Chen H, Gurney JG, et al. Health status of adult long-term survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. JAMA. 2003 Sep 24;290(12):1583–92.
Hudson, Melissa M., et al. “Health status of adult long-term survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.JAMA, vol. 290, no. 12, Sept. 2003, pp. 1583–92. Pubmed, doi:10.1001/jama.290.12.1583.
Hudson MM, Mertens AC, Yasui Y, Hobbie W, Chen H, Gurney JG, Yeazel M, Recklitis CJ, Marina N, Robison LR, Oeffinger KC, Childhood Cancer Survivor Study Investigators. Health status of adult long-term survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. JAMA. 2003 Sep 24;290(12):1583–1592.
Journal cover image

Published In

JAMA

DOI

EISSN

1538-3598

Publication Date

September 24, 2003

Volume

290

Issue

12

Start / End Page

1583 / 1592

Location

United States

Related Subject Headings

  • Survivors
  • Socioeconomic Factors
  • Siblings
  • Regression Analysis
  • Neoplasms
  • Middle Aged
  • Male
  • Infant
  • Humans
  • Health Surveys