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Abdominal obesity, liver fat, and muscle composition in survivors of childhood acute lymphoblastic leukemia.

Publication ,  Journal Article
Janiszewski, PM; Oeffinger, KC; Church, TS; Dunn, AL; Eshelman, DA; Victor, RG; Brooks, S; Turoff, AJ; Sinclair, E; Murray, JC; Bashore, L; Ross, R
Published in: J Clin Endocrinol Metab
October 2007

CONTEXT: Survivors of childhood acute lymphoblastic leukemia (ALL) become obese, and are at increased risk for morbidity and mortality post therapy. OBJECTIVE: We determined the association of cranial radiotherapy (CRT) and/or sex with levels of total, regional, and ectopic fat storage, metabolic risk, IGF-I, and leptin in adult ALL survivors. DESIGN, SETTING, PATIENTS: A cross-sectional analysis of 52 male (15 CRT treated) and 62 female (24 CRT treated) young adult ALL survivors was conducted. MAIN OUTCOMES: We assessed levels of visceral fat, sc abdominal and thigh fat, and liver and muscle fat using computed tomography, total fat and lean body mass using dual-energy x-ray absorptiometry, and IGF-I and leptin levels by radioimmunoassay. RESULTS: Controlled for age and race, ALL survivors treated with CRT had higher levels of abdominal and visceral fat, body fat percentage, metabolic risk (insulin resistance and dyslipidemia), and leptin but lower lean mass and IGF-I levels than non-CRT survivors (P 0.1). CONCLUSION: Among young adult ALL survivors, CRT is a risk factor for elevated total, abdominal, and visceral adiposity, a reduced fat-free mass, elevated metabolic risk, and altered IGF-I and leptin levels.

Duke Scholars

Published In

J Clin Endocrinol Metab

DOI

ISSN

0021-972X

Publication Date

October 2007

Volume

92

Issue

10

Start / End Page

3816 / 3821

Location

United States

Related Subject Headings

  • Survivors
  • Sex Distribution
  • Risk Factors
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Obesity
  • Muscle, Skeletal
  • Morbidity
  • Male
  • Liver
  • Leptin
 

Citation

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Chicago
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MLA
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Janiszewski, P. M., Oeffinger, K. C., Church, T. S., Dunn, A. L., Eshelman, D. A., Victor, R. G., … Ross, R. (2007). Abdominal obesity, liver fat, and muscle composition in survivors of childhood acute lymphoblastic leukemia. J Clin Endocrinol Metab, 92(10), 3816–3821. https://doi.org/10.1210/jc.2006-2178
Janiszewski, Peter M., Kevin C. Oeffinger, Timothy S. Church, Andrea L. Dunn, Debra A. Eshelman, Ronald G. Victor, Sandra Brooks, et al. “Abdominal obesity, liver fat, and muscle composition in survivors of childhood acute lymphoblastic leukemia.J Clin Endocrinol Metab 92, no. 10 (October 2007): 3816–21. https://doi.org/10.1210/jc.2006-2178.
Janiszewski PM, Oeffinger KC, Church TS, Dunn AL, Eshelman DA, Victor RG, et al. Abdominal obesity, liver fat, and muscle composition in survivors of childhood acute lymphoblastic leukemia. J Clin Endocrinol Metab. 2007 Oct;92(10):3816–21.
Janiszewski, Peter M., et al. “Abdominal obesity, liver fat, and muscle composition in survivors of childhood acute lymphoblastic leukemia.J Clin Endocrinol Metab, vol. 92, no. 10, Oct. 2007, pp. 3816–21. Pubmed, doi:10.1210/jc.2006-2178.
Janiszewski PM, Oeffinger KC, Church TS, Dunn AL, Eshelman DA, Victor RG, Brooks S, Turoff AJ, Sinclair E, Murray JC, Bashore L, Ross R. Abdominal obesity, liver fat, and muscle composition in survivors of childhood acute lymphoblastic leukemia. J Clin Endocrinol Metab. 2007 Oct;92(10):3816–3821.
Journal cover image

Published In

J Clin Endocrinol Metab

DOI

ISSN

0021-972X

Publication Date

October 2007

Volume

92

Issue

10

Start / End Page

3816 / 3821

Location

United States

Related Subject Headings

  • Survivors
  • Sex Distribution
  • Risk Factors
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Obesity
  • Muscle, Skeletal
  • Morbidity
  • Male
  • Liver
  • Leptin