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Late-occurring stroke among long-term survivors of childhood leukemia and brain tumors: a report from the Childhood Cancer Survivor Study.

Publication ,  Journal Article
Bowers, DC; Liu, Y; Leisenring, W; McNeil, E; Stovall, M; Gurney, JG; Robison, LL; Packer, RJ; Oeffinger, KC
Published in: J Clin Oncol
November 20, 2006

PURPOSE: This report examines the incidence of and risk factors for strokes that occur in > or = 5-year survivors of childhood leukemia and brain tumors. PATIENTS AND METHODS: The rate of first occurrence of self-reported late-occurring strokes was determined for leukemia survivors (n = 4,828), brain tumor survivors (n = 1,871), and a comparison group of a random sample of cancer survivor siblings (n = 3,846). Relative risks (RRs) and 95% confidence intervals (CIs) of stroke by treatment exposures were examined by multivariate analyses. RESULTS: Thirty-seven leukemia survivors and 63 brain tumor survivors reported a late-occurring stroke. The rate of late-occurring stroke for leukemia survivors was 57.9 per 100,000 person-years (95% CI, 41.2 to 78.7). The RR of stroke for leukemia survivors compared with the sibling comparison group was 6.4 (95% CI, 3.0 to 13.8; P < .0001). The rate of late-occurring stroke for brain tumor survivors was 267.6 per 100,000 person-years (95% CI, 206.8 to 339.2). The RR of stroke for brain tumor survivors compared with the sibling comparison group was 29.0 (95% CI, 13.8 to 60.6; P < .0001). Mean cranial radiation therapy (CRT) dose of > or = 30 Gy was associated with an increased risk in both leukemia and brain tumor survivors in a dose-dependent fashion, with the highest risk after doses of > or = 50 Gy CRT. CONCLUSION: Survivors of childhood leukemia and brain tumors, particularly those with brain tumors treated with CRT at doses of greater than 30 Gy, are at an increased risk of stroke.

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Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

November 20, 2006

Volume

24

Issue

33

Start / End Page

5277 / 5282

Location

United States

Related Subject Headings

  • United States
  • Time Factors
  • Survivors
  • Stroke
  • Siblings
  • Risk Factors
  • Risk Assessment
  • Radiotherapy Dosage
  • Oncology & Carcinogenesis
  • Odds Ratio
 

Citation

APA
Chicago
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MLA
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Bowers, D. C., Liu, Y., Leisenring, W., McNeil, E., Stovall, M., Gurney, J. G., … Oeffinger, K. C. (2006). Late-occurring stroke among long-term survivors of childhood leukemia and brain tumors: a report from the Childhood Cancer Survivor Study. J Clin Oncol, 24(33), 5277–5282. https://doi.org/10.1200/JCO.2006.07.2884
Bowers, Daniel C., Yan Liu, Wendy Leisenring, Elizabeth McNeil, Marilyn Stovall, James G. Gurney, Leslie L. Robison, Roger J. Packer, and Kevin C. Oeffinger. “Late-occurring stroke among long-term survivors of childhood leukemia and brain tumors: a report from the Childhood Cancer Survivor Study.J Clin Oncol 24, no. 33 (November 20, 2006): 5277–82. https://doi.org/10.1200/JCO.2006.07.2884.
Bowers DC, Liu Y, Leisenring W, McNeil E, Stovall M, Gurney JG, et al. Late-occurring stroke among long-term survivors of childhood leukemia and brain tumors: a report from the Childhood Cancer Survivor Study. J Clin Oncol. 2006 Nov 20;24(33):5277–82.
Bowers, Daniel C., et al. “Late-occurring stroke among long-term survivors of childhood leukemia and brain tumors: a report from the Childhood Cancer Survivor Study.J Clin Oncol, vol. 24, no. 33, Nov. 2006, pp. 5277–82. Pubmed, doi:10.1200/JCO.2006.07.2884.
Bowers DC, Liu Y, Leisenring W, McNeil E, Stovall M, Gurney JG, Robison LL, Packer RJ, Oeffinger KC. Late-occurring stroke among long-term survivors of childhood leukemia and brain tumors: a report from the Childhood Cancer Survivor Study. J Clin Oncol. 2006 Nov 20;24(33):5277–5282.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

November 20, 2006

Volume

24

Issue

33

Start / End Page

5277 / 5282

Location

United States

Related Subject Headings

  • United States
  • Time Factors
  • Survivors
  • Stroke
  • Siblings
  • Risk Factors
  • Risk Assessment
  • Radiotherapy Dosage
  • Oncology & Carcinogenesis
  • Odds Ratio