Type III Hypersensitivity Reaction to Subcutaneous Insulin Preparations in a Type 1 Diabetic.
Management of type 1 diabetes in patients who have insulin hypersensitivity is a clinical challenge and places patients at risk for recurrent diabetic ketoacidosis (DKA). Hypersensitivity reactions can be due to the patient's response to the insulin molecule itself or one of the injection's non-insulin components. It is therefore crucial for clinicians to quickly recognize the type of hypersensitivity reaction that is occurring and identify potentially immunogenic additives for the purpose of directing therapy as various insulin preparations have differing ingredients. We present the case of a 23-year-old diabetic female with common variable immunodeficiency (CVID) and autoimmune enteropathy who developed a type III hypersensitivity reaction to multiple formulations of subcutaneous insulin after years of use and the challenges of devising a long-term management strategy.
Duke Scholars
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Related Subject Headings
- Young Adult
- Insulin
- Injections, Subcutaneous
- Immunologic Factors
- Humans
- General & Internal Medicine
- Female
- Drug Hypersensitivity
- Diabetes Mellitus, Type 1
- 4206 Public health
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Young Adult
- Insulin
- Injections, Subcutaneous
- Immunologic Factors
- Humans
- General & Internal Medicine
- Female
- Drug Hypersensitivity
- Diabetes Mellitus, Type 1
- 4206 Public health