Skip to main content
Journal cover image

Lipid sugar carriers at the extremes: The phosphodolichols Archaea use in N-glycosylation.

Publication ,  Journal Article
Eichler, J; Guan, Z
Published in: Biochim Biophys Acta Mol Cell Biol Lipids
June 2017

N-glycosylation, a post-translational modification whereby glycans are covalently linked to select Asn residues of target proteins, occurs in all three domains of life. Across evolution, the N-linked glycans are initially assembled on phosphorylated cytoplasmically-oriented polyisoprenoids, with polyprenol (mainly C55 undecaprenol) fulfilling this role in Bacteria and dolichol assuming this function in Eukarya and Archaea. The eukaryal and archaeal versions of dolichol can, however, be distinguished on the basis of their length, degree of saturation and by other traits. As is true for many facets of their biology, Archaea, best known in their capacity as extremophiles, present unique approaches for synthesizing phosphodolichols. At the same time, general insight into the assembly and processing of glycan-bearing phosphodolichols has come from studies of the archaeal enzymes responsible. In this review, these and other aspects of archaeal phosphodolichol biology are addressed.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Biochim Biophys Acta Mol Cell Biol Lipids

DOI

ISSN

1388-1981

Publication Date

June 2017

Volume

1862

Issue

6

Start / End Page

589 / 599

Location

Netherlands

Related Subject Headings

  • Glycosylation
  • Dolichol Phosphates
  • Carbohydrates
  • Archaea
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Eichler, J., & Guan, Z. (2017). Lipid sugar carriers at the extremes: The phosphodolichols Archaea use in N-glycosylation. Biochim Biophys Acta Mol Cell Biol Lipids, 1862(6), 589–599. https://doi.org/10.1016/j.bbalip.2017.03.005
Eichler, Jerry, and Ziqiang Guan. “Lipid sugar carriers at the extremes: The phosphodolichols Archaea use in N-glycosylation.Biochim Biophys Acta Mol Cell Biol Lipids 1862, no. 6 (June 2017): 589–99. https://doi.org/10.1016/j.bbalip.2017.03.005.
Eichler J, Guan Z. Lipid sugar carriers at the extremes: The phosphodolichols Archaea use in N-glycosylation. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Jun;1862(6):589–99.
Eichler, Jerry, and Ziqiang Guan. “Lipid sugar carriers at the extremes: The phosphodolichols Archaea use in N-glycosylation.Biochim Biophys Acta Mol Cell Biol Lipids, vol. 1862, no. 6, June 2017, pp. 589–99. Pubmed, doi:10.1016/j.bbalip.2017.03.005.
Eichler J, Guan Z. Lipid sugar carriers at the extremes: The phosphodolichols Archaea use in N-glycosylation. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Jun;1862(6):589–599.
Journal cover image

Published In

Biochim Biophys Acta Mol Cell Biol Lipids

DOI

ISSN

1388-1981

Publication Date

June 2017

Volume

1862

Issue

6

Start / End Page

589 / 599

Location

Netherlands

Related Subject Headings

  • Glycosylation
  • Dolichol Phosphates
  • Carbohydrates
  • Archaea
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences