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Breaking the bilayer: OMV formation during environmental transitions.

Publication ,  Journal Article
Bonnington, KE; Kuehn, MJ
Published in: Microb Cell
February 3, 2017

Gram-negative bacteria maintain the barrier properties of the outer membrane (OM) in a wide array of physiological conditions despite their inability to degrade lipopolysaccharide (LPS) and protein material present in the outer leaflet of the OM. Through characterization of the native dynamics of outer membrane LPS change we recently described a mechanism in which these diderm organisms overcome this design flaw. In response to different environmental stimuli Salmonellaenterica modulates the export of specific structural variants of lipid A via outer membrane vesicles (OMVs). We proposed that the polymorphic model for regulation of membrane lipid content could largely account for the structural differences between secreted and retained lipid A species. However, differences in OMV production levels and size observed between environmental conditions remain unexplained. Further exploration into the relationship between OMV production level and content specificity may shed light onto the enigmatic mechanisms of OMV formation.

Duke Scholars

Published In

Microb Cell

DOI

ISSN

2311-2638

Publication Date

February 3, 2017

Volume

4

Issue

2

Start / End Page

64 / 66

Location

Austria
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bonnington, K. E., & Kuehn, M. J. (2017). Breaking the bilayer: OMV formation during environmental transitions. Microb Cell, 4(2), 64–66. https://doi.org/10.15698/mic2017.02.558
Bonnington, Katherine E., and Meta J. Kuehn. “Breaking the bilayer: OMV formation during environmental transitions.Microb Cell 4, no. 2 (February 3, 2017): 64–66. https://doi.org/10.15698/mic2017.02.558.
Bonnington KE, Kuehn MJ. Breaking the bilayer: OMV formation during environmental transitions. Microb Cell. 2017 Feb 3;4(2):64–6.
Bonnington, Katherine E., and Meta J. Kuehn. “Breaking the bilayer: OMV formation during environmental transitions.Microb Cell, vol. 4, no. 2, Feb. 2017, pp. 64–66. Pubmed, doi:10.15698/mic2017.02.558.
Bonnington KE, Kuehn MJ. Breaking the bilayer: OMV formation during environmental transitions. Microb Cell. 2017 Feb 3;4(2):64–66.

Published In

Microb Cell

DOI

ISSN

2311-2638

Publication Date

February 3, 2017

Volume

4

Issue

2

Start / End Page

64 / 66

Location

Austria