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Quality of life after breast cancer diagnosis and survival.

Publication ,  Journal Article
Epplein, M; Zheng, Y; Zheng, W; Chen, Z; Gu, K; Penson, D; Lu, W; Shu, X-O
Published in: J Clin Oncol
February 1, 2011

PURPOSE: To examine the association of quality of life (QOL) after diagnosis of breast cancer with mortality and recurrence. PATIENTS AND METHODS: From 2002 to 2004, a total of 2,230 breast cancer survivors completed the General Quality of Life Inventory-74 6 months after diagnosis as part of the Shanghai Breast Cancer Survivor Study. Also collected at baseline was information on demographic and clinical characteristics. At 36 months postdiagnosis, 1,845 of these women were re-evaluated for QOL. Outcomes were ascertained by in-person interview and record linkage to the vital statistics registry. The association of QOL with total mortality and cancer recurrence was assessed by using Cox regression analysis. RESULTS: During a median follow-up of 4.8 years after the 6-month postdiagnosis QOL assessment, 284 deaths were identified. Recurrence was documented in 267 patients after 108 patients with stage IV breast cancer or recurrence before study enrollment were excluded. Women with the highest tertile of social well-being QOL score, compared with those with the lowest score, had a 38% decreased risk of mortality (95% CI, 0.46 to 0.85; P for trend = .002) and a 48% decreased risk of breast cancer recurrence (95% CI, 0.38 to 0.71; P for trend < .001). QOL assessed at 36 months postdiagnosis was not significantly associated with subsequent risk of mortality or recurrence. CONCLUSION: Social well-being in the first year after cancer diagnosis is a significant prognostic factor for breast cancer recurrence or mortality, suggesting a possible avenue of intervention by maintaining or enhancing social support for women soon after their breast cancer diagnosis to improve disease outcomes.

Duke Scholars

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Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

February 1, 2011

Volume

29

Issue

4

Start / End Page

406 / 412

Location

United States

Related Subject Headings

  • Young Adult
  • Time Factors
  • Survivors
  • Surveys and Questionnaires
  • Social Support
  • Risk Factors
  • Risk Assessment
  • Registries
  • Recurrence
  • Quality of Life
 

Citation

APA
Chicago
ICMJE
MLA
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Epplein, M., Zheng, Y., Zheng, W., Chen, Z., Gu, K., Penson, D., … Shu, X.-O. (2011). Quality of life after breast cancer diagnosis and survival. J Clin Oncol, 29(4), 406–412. https://doi.org/10.1200/JCO.2010.30.6951
Epplein, Meira, Ying Zheng, Wei Zheng, Zhi Chen, Kai Gu, David Penson, Wei Lu, and Xiao-Ou Shu. “Quality of life after breast cancer diagnosis and survival.J Clin Oncol 29, no. 4 (February 1, 2011): 406–12. https://doi.org/10.1200/JCO.2010.30.6951.
Epplein M, Zheng Y, Zheng W, Chen Z, Gu K, Penson D, et al. Quality of life after breast cancer diagnosis and survival. J Clin Oncol. 2011 Feb 1;29(4):406–12.
Epplein, Meira, et al. “Quality of life after breast cancer diagnosis and survival.J Clin Oncol, vol. 29, no. 4, Feb. 2011, pp. 406–12. Pubmed, doi:10.1200/JCO.2010.30.6951.
Epplein M, Zheng Y, Zheng W, Chen Z, Gu K, Penson D, Lu W, Shu X-O. Quality of life after breast cancer diagnosis and survival. J Clin Oncol. 2011 Feb 1;29(4):406–412.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

February 1, 2011

Volume

29

Issue

4

Start / End Page

406 / 412

Location

United States

Related Subject Headings

  • Young Adult
  • Time Factors
  • Survivors
  • Surveys and Questionnaires
  • Social Support
  • Risk Factors
  • Risk Assessment
  • Registries
  • Recurrence
  • Quality of Life