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Association of Helicobacter pylori infection and diet on the risk of gastric cancer: a case-control study in Hawaii.

Publication ,  Journal Article
Epplein, M; Nomura, AMY; Hankin, JH; Blaser, MJ; Perez-Perez, G; Stemmermann, GN; Wilkens, LR; Kolonel, LN
Published in: Cancer Causes Control
October 2008

OBJECTIVE: The risk factors most strongly associated with gastric cancer are the gastric bacteria Helicobacter pylori and diet. Utilizing data from a case-control study among residents in Hawaii, we examined the association of diet, presence of H. pylori, and non-cardia gastric cancer risk. METHODS: Serum taken at diagnosis for cases (n = 212) and at interview for controls (n = 336) was assayed for IgG antibodies to H. pylori group antigens and to a recombinant fragment of the cytotoxin-associated antigen A (CagA) protein, and subjects completed food frequency questionnaires. Risk measures were calculated using logistic regression. The likelihood ratio test was used to assess interactions. RESULTS: Inverse associations were found between gastric cancer risk and increasing intake of several micronutrients and vegetables among all individuals. For H. pylori/CagA-positive subjects, significant trends were present for total, green, and yellow vegetables, while a significant trend was present only for yellow vegetables among H. pylori/CagA-negative individuals. For intestinal gastric cancer, there was a suggestion that intake of vegetables, especially cruciferous vegetables, had a stronger protective effect for the H. pylori/CagA-positive group. CONCLUSIONS: Diet may play a greater role in the etiology of non-cardia gastric cancer among individuals with evidence of H. pylori infection than among those without.

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Published In

Cancer Causes Control

DOI

EISSN

1573-7225

Publication Date

October 2008

Volume

19

Issue

8

Start / End Page

869 / 877

Location

Netherlands

Related Subject Headings

  • Stomach Neoplasms
  • SEER Program
  • Risk Factors
  • Middle Aged
  • Male
  • Immunoglobulin G
  • Humans
  • Helicobacter pylori
  • Helicobacter Infections
  • Hawaii
 

Citation

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Chicago
ICMJE
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Epplein, M., Nomura, A. M. Y., Hankin, J. H., Blaser, M. J., Perez-Perez, G., Stemmermann, G. N., … Kolonel, L. N. (2008). Association of Helicobacter pylori infection and diet on the risk of gastric cancer: a case-control study in Hawaii. Cancer Causes Control, 19(8), 869–877. https://doi.org/10.1007/s10552-008-9149-2
Epplein, Meira, Abraham M. Y. Nomura, Jean H. Hankin, Martin J. Blaser, Guillermo Perez-Perez, Grant N. Stemmermann, Lynne R. Wilkens, and Laurence N. Kolonel. “Association of Helicobacter pylori infection and diet on the risk of gastric cancer: a case-control study in Hawaii.Cancer Causes Control 19, no. 8 (October 2008): 869–77. https://doi.org/10.1007/s10552-008-9149-2.
Epplein M, Nomura AMY, Hankin JH, Blaser MJ, Perez-Perez G, Stemmermann GN, et al. Association of Helicobacter pylori infection and diet on the risk of gastric cancer: a case-control study in Hawaii. Cancer Causes Control. 2008 Oct;19(8):869–77.
Epplein, Meira, et al. “Association of Helicobacter pylori infection and diet on the risk of gastric cancer: a case-control study in Hawaii.Cancer Causes Control, vol. 19, no. 8, Oct. 2008, pp. 869–77. Pubmed, doi:10.1007/s10552-008-9149-2.
Epplein M, Nomura AMY, Hankin JH, Blaser MJ, Perez-Perez G, Stemmermann GN, Wilkens LR, Kolonel LN. Association of Helicobacter pylori infection and diet on the risk of gastric cancer: a case-control study in Hawaii. Cancer Causes Control. 2008 Oct;19(8):869–877.
Journal cover image

Published In

Cancer Causes Control

DOI

EISSN

1573-7225

Publication Date

October 2008

Volume

19

Issue

8

Start / End Page

869 / 877

Location

Netherlands

Related Subject Headings

  • Stomach Neoplasms
  • SEER Program
  • Risk Factors
  • Middle Aged
  • Male
  • Immunoglobulin G
  • Humans
  • Helicobacter pylori
  • Helicobacter Infections
  • Hawaii