Abstract 1027: Helicobacter pylori blood biomarkers for gastric cancer risk in the Shanghai Men's Health Study

Background: Helicobacter pylori is the leading identified risk factor for distal gastric cancer, yet only a fraction of infected individuals ever develop neoplasia. To identify potential risk markers in a Chinese population where over 90% of individuals are infected with H. pylori, we assessed the association between antibodies to 15 Helicobacter pylori proteins and gastric cancer risk in a case-control study nested in a population-based cohort study. Methods: Each incident distal gastric cancer case (n = 227) identified between 2002 and 2009 among members of the Shanghai Men's Health Study was matched to two controls based on age, timing of blood collection, and recent antibiotic use. Serum levels of antibodies to 15 Helicobacter pylori proteins were assessed using multiplex serology. Multivariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Results: Sero-positivity to three (Omp, HP0305, HyuA) of fifteen proteins assessed were associated with an approximate two-fold significantly increased risk for gastric cancer. When excluding cases who were diagnosed within two years of study enrollment (and their matched controls), sero-positivity to two additional proteins (HpaA and NapA) showed significant associations with risk. An association with CagA sero-positivity was also suggested. Compared to individuals with ≤3 sero-positive results to the six virulent proteins identified in this population, individuals with 4-5 sero-positive results were at a two-fold increased risk (OR=1.93, 95% CI: 1.25-3.00) and individuals sero-positive to all 6 proteins had an over 3-fold increase in risk (OR=3.31, 95% CI: 1.86-5.89) for distal gastric cancer. Among individuals least likely to have begun cascade of events leading to gastric cancer, these associations were even stronger (OR=2.74, 95% CI: 1.58-4.73 and OR=4.72, 95% CI: 2.22-10.03, respectively). Conclusions: In the Chinese population, among whom H. pylori-infection is highly prevalent, increasing number of sero-positives to six H. pylori proteins (Omp, HP0305, HyuA, HpaA, CagA, and VacA) may predict the risk of gastric cancer.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1027. doi:1538-7445.AM2012-1027

Duke Scholars

Author Meira Epplein Population Health Sciences