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Lessons learned from the anaerobe survey: historical perspective and review of the most recent data (2005-2007).

Publication ,  Journal Article
Snydman, DR; Jacobus, NV; McDermott, LA; Golan, Y; Hecht, DW; Goldstein, EJC; Harrell, L; Jenkins, S; Newton, D; Pierson, C; Rihs, JD; Yu, VL ...
Published in: Clin Infect Dis
January 1, 2010

BACKGROUND: The rationale and lessons learned through the evolution of the National Survey for the Susceptibility of Bacteroides fragilis Group from its initiation in 1981 through 2007 are reviewed here. The survey was conceived in 1980 to track emerging antimicrobial resistance in Bacteroides species. METHODS: Data from the last 11 years of the survey (1997-2007), including 6574 isolates from 13 medical centers, were analyzed for in vitro antimicrobial resistance to both frequently used and newly developed anti-anaerobic agents. The minimum inhibitory concentrations of the antibiotics were determined using agar dilution in accordance with Clinical and Laboratory Standards Institute recommendations. RESULTS: The analyses revealed that the carbapenems (imipenem, meropenem, ertapenem, and doripenem) and piperacillin-tazobactam were the most active agents against these pathogens, with resistance rates of 0.9%-2.3%. In the most recent 3 years of the survey (2005-2007), resistance to some agents was shown to depend on the species, such as ampicillin-sulbactam against Bacteroides distasonis (20.6%) and tigecycline against Bacteroides uniformis and Bacteroides eggerthii ( approximately 7%). Very high resistance rates (>50%) were noted for moxifloxacin and trovafloxacin, particularly against Bacteroides vulgatus. During that period of study, non-B. fragilis Bacteroides species had >40% resistance to clindamycin. Metronidazole-resistant Bacteroides strains were also first reported during that period. CONCLUSIONS: In summary, resistance to antibiotics was greater among non-B. fragilis Bacteroides species than among B. fragilis and was especially greater among species with a low frequency of isolation, such as Bacteroides caccae and B. uniformis. The emergence of resistance among the non-B. fragilis Bacteroides species underscores the need for speciation of B. fragilis group isolates and for clinicians to be aware of associations between species and drug resistance.

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Published In

Clin Infect Dis

DOI

EISSN

1537-6591

Publication Date

January 1, 2010

Volume

50 Suppl 1

Start / End Page

S26 / S33

Location

United States

Related Subject Headings

  • Microbiology
  • Microbial Sensitivity Tests
  • Humans
  • Drug Resistance, Bacterial
  • Data Collection
  • Bacteroides fragilis
  • Bacteroides Infections
  • Bacteroides
  • Bacteria, Anaerobic
  • Bacteremia
 

Citation

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Snydman, D. R., Jacobus, N. V., McDermott, L. A., Golan, Y., Hecht, D. W., Goldstein, E. J. C., … Gorbach, S. L. (2010). Lessons learned from the anaerobe survey: historical perspective and review of the most recent data (2005-2007). Clin Infect Dis, 50 Suppl 1, S26–S33. https://doi.org/10.1086/647940
Snydman, David R., Nilda V. Jacobus, Laura A. McDermott, Yoav Golan, David W. Hecht, Ellie J. C. Goldstein, Lizzie Harrell, et al. “Lessons learned from the anaerobe survey: historical perspective and review of the most recent data (2005-2007).Clin Infect Dis 50 Suppl 1 (January 1, 2010): S26–33. https://doi.org/10.1086/647940.
Snydman DR, Jacobus NV, McDermott LA, Golan Y, Hecht DW, Goldstein EJC, et al. Lessons learned from the anaerobe survey: historical perspective and review of the most recent data (2005-2007). Clin Infect Dis. 2010 Jan 1;50 Suppl 1:S26–33.
Snydman, David R., et al. “Lessons learned from the anaerobe survey: historical perspective and review of the most recent data (2005-2007).Clin Infect Dis, vol. 50 Suppl 1, Jan. 2010, pp. S26–33. Pubmed, doi:10.1086/647940.
Snydman DR, Jacobus NV, McDermott LA, Golan Y, Hecht DW, Goldstein EJC, Harrell L, Jenkins S, Newton D, Pierson C, Rihs JD, Yu VL, Venezia R, Finegold SM, Rosenblatt JE, Gorbach SL. Lessons learned from the anaerobe survey: historical perspective and review of the most recent data (2005-2007). Clin Infect Dis. 2010 Jan 1;50 Suppl 1:S26–S33.
Journal cover image

Published In

Clin Infect Dis

DOI

EISSN

1537-6591

Publication Date

January 1, 2010

Volume

50 Suppl 1

Start / End Page

S26 / S33

Location

United States

Related Subject Headings

  • Microbiology
  • Microbial Sensitivity Tests
  • Humans
  • Drug Resistance, Bacterial
  • Data Collection
  • Bacteroides fragilis
  • Bacteroides Infections
  • Bacteroides
  • Bacteria, Anaerobic
  • Bacteremia