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Perceived stress and reported cognitive symptoms among Georgia patients with systemic lupus erythematosus.

Publication ,  Journal Article
Plantinga, L; Lim, SS; Bowling, CB; Drenkard, C
Published in: Lupus
September 2017

Objective To examine associations of perceived stress with cognitive symptoms among adults with systemic lupus erythematosus (SLE). Methods Among 777 adult (≥18 years) SLE patients, the association of Perceived Stress Scale (PSS) scores with two self-reported cognitive symptoms was examined: forgetfulness (severe/moderate vs. mild/none; from the Systemic Lupus Activity Questionnaire) and difficulty concentrating (all/most vs. some/little/none of the time; from the Lupus Impact Tracker). The study used multivariable logistic regression to estimate the odds ratios (ORs) per minimal important difference (MID = 0.5*SD) of PSS score and cognitive symptoms. Results Forgetfulness and difficulty concentrating were reported by 41.7% and 29.5%, respectively. Women and those with less education and high disease activity had higher PSS scores and were more likely to report cognitive symptoms than their counterparts. With adjustment for age, race, sex, education, and disease activity, each MID increase in PSS score was associated with higher prevalence of forgetfulness (OR = 1.43, 95% CI 1.29-1.47) and difficulty concentrating (OR = 2.19, 95% CI 1.90-2.52). No substantial differences in this association by age, race, sex, or disease activity were noted. Conclusions SLE patients, particularly those with high disease activity, report a high burden of cognitive symptoms, for which stress may be a modifiable risk factor.

Duke Scholars

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Published In

Lupus

DOI

EISSN

1477-0962

Publication Date

September 2017

Volume

26

Issue

10

Start / End Page

1064 / 1071

Location

England

Related Subject Headings

  • Surveys and Questionnaires
  • Stress, Psychological
  • Severity of Illness Index
  • Self Report
  • Risk Factors
  • Prevalence
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Lupus Erythematosus, Systemic
 

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Plantinga, L., Lim, S. S., Bowling, C. B., & Drenkard, C. (2017). Perceived stress and reported cognitive symptoms among Georgia patients with systemic lupus erythematosus. Lupus, 26(10), 1064–1071. https://doi.org/10.1177/0961203317693095
Plantinga, L., S. S. Lim, C. B. Bowling, and C. Drenkard. “Perceived stress and reported cognitive symptoms among Georgia patients with systemic lupus erythematosus.Lupus 26, no. 10 (September 2017): 1064–71. https://doi.org/10.1177/0961203317693095.
Plantinga L, Lim SS, Bowling CB, Drenkard C. Perceived stress and reported cognitive symptoms among Georgia patients with systemic lupus erythematosus. Lupus. 2017 Sep;26(10):1064–71.
Plantinga, L., et al. “Perceived stress and reported cognitive symptoms among Georgia patients with systemic lupus erythematosus.Lupus, vol. 26, no. 10, Sept. 2017, pp. 1064–71. Pubmed, doi:10.1177/0961203317693095.
Plantinga L, Lim SS, Bowling CB, Drenkard C. Perceived stress and reported cognitive symptoms among Georgia patients with systemic lupus erythematosus. Lupus. 2017 Sep;26(10):1064–1071.
Journal cover image

Published In

Lupus

DOI

EISSN

1477-0962

Publication Date

September 2017

Volume

26

Issue

10

Start / End Page

1064 / 1071

Location

England

Related Subject Headings

  • Surveys and Questionnaires
  • Stress, Psychological
  • Severity of Illness Index
  • Self Report
  • Risk Factors
  • Prevalence
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Lupus Erythematosus, Systemic