Skip to main content

Enhancing Insights into Pulmonary Vascular Disease through a Precision Medicine Approach. A Joint NHLBI-Cardiovascular Medical Research and Education Fund Workshop Report.

Publication ,  Journal Article
Newman, JH; Rich, S; Abman, SH; Alexander, JH; Barnard, J; Beck, GJ; Benza, RL; Bull, TM; Chan, SY; Chun, HJ; Doogan, D; Dupuis, J; Geraci, M ...
Published in: Am J Respir Crit Care Med
June 15, 2017

The Division of Lung Diseases of the NHLBI and the Cardiovascular Medical Education and Research Fund held a workshop to discuss how to leverage the anticipated scientific output from the recently launched "Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics" (PVDOMICS) program to develop newer approaches to pulmonary vascular disease. PVDOMICS is a collaborative, protocol-driven network to analyze all patient populations with pulmonary hypertension to define novel pulmonary vascular disease (PVD) phenotypes. Stakeholders, including basic, translational, and clinical investigators; clinicians; patient advocacy organizations; regulatory agencies; and pharmaceutical industry experts, joined to discuss the application of precision medicine to PVD clinical trials. Recommendations were generated for discussion of research priorities in line with NHLBI Strategic Vision Goals that include: (1) A national effort, involving all the stakeholders, should seek to coordinate biosamples and biodata from all funded programs to a web-based repository so that information can be shared and correlated with other research projects. Example programs sponsored by NHLBI include PVDOMICS, Pulmonary Hypertension Breakthrough Initiative, the National Biological Sample and Data Repository for PAH, and the National Precision Medicine Initiative. (2) A task force to develop a master clinical trials protocol for PVD to apply precision medicine principles to future clinical trials. Specific features include: (a) adoption of smaller clinical trials that incorporate biomarker-guided enrichment strategies, using adaptive and innovative statistical designs; and (b) development of newer endpoints that reflect well-defined and clinically meaningful changes. (3) Development of updated and systematic variables in imaging, hemodynamic, cellular, genomic, and metabolic tests that will help precisely identify individual and shared features of PVD and serve as the basis of novel phenotypes for therapeutic interventions.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Am J Respir Crit Care Med

DOI

EISSN

1535-4970

Publication Date

June 15, 2017

Volume

195

Issue

12

Start / End Page

1661 / 1670

Location

United States

Related Subject Headings

  • United States
  • Respiratory System
  • Precision Medicine
  • National Heart, Lung, and Blood Institute (U.S.)
  • Hypertension, Pulmonary
  • Humans
  • Education
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Newman, J. H., Rich, S., Abman, S. H., Alexander, J. H., Barnard, J., Beck, G. J., … Xiao, L. (2017). Enhancing Insights into Pulmonary Vascular Disease through a Precision Medicine Approach. A Joint NHLBI-Cardiovascular Medical Research and Education Fund Workshop Report. Am J Respir Crit Care Med, 195(12), 1661–1670. https://doi.org/10.1164/rccm.201701-0150WS
Newman, John H., Stuart Rich, Steven H. Abman, John H. Alexander, John Barnard, Gerald J. Beck, Raymond L. Benza, et al. “Enhancing Insights into Pulmonary Vascular Disease through a Precision Medicine Approach. A Joint NHLBI-Cardiovascular Medical Research and Education Fund Workshop Report.Am J Respir Crit Care Med 195, no. 12 (June 15, 2017): 1661–70. https://doi.org/10.1164/rccm.201701-0150WS.
Newman JH, Rich S, Abman SH, Alexander JH, Barnard J, Beck GJ, et al. Enhancing Insights into Pulmonary Vascular Disease through a Precision Medicine Approach. A Joint NHLBI-Cardiovascular Medical Research and Education Fund Workshop Report. Am J Respir Crit Care Med. 2017 Jun 15;195(12):1661–70.
Newman, John H., et al. “Enhancing Insights into Pulmonary Vascular Disease through a Precision Medicine Approach. A Joint NHLBI-Cardiovascular Medical Research and Education Fund Workshop Report.Am J Respir Crit Care Med, vol. 195, no. 12, June 2017, pp. 1661–70. Pubmed, doi:10.1164/rccm.201701-0150WS.
Newman JH, Rich S, Abman SH, Alexander JH, Barnard J, Beck GJ, Benza RL, Bull TM, Chan SY, Chun HJ, Doogan D, Dupuis J, Erzurum SC, Frantz RP, Geraci M, Gillies H, Gladwin M, Gray MP, Hemnes AR, Herbst RS, Hernandez AF, Hill NS, Horn EM, Hunter K, Jing Z-C, Johns R, Kaul S, Kawut SM, Lahm T, Leopold JA, Lewis GD, Mathai SC, McLaughlin VV, Michelakis ED, Nathan SD, Nichols W, Page G, Rabinovitch M, Rich J, Rischard F, Rounds S, Shah SJ, Tapson VF, Lowy N, Stockbridge N, Weinmann G, Xiao L. Enhancing Insights into Pulmonary Vascular Disease through a Precision Medicine Approach. A Joint NHLBI-Cardiovascular Medical Research and Education Fund Workshop Report. Am J Respir Crit Care Med. 2017 Jun 15;195(12):1661–1670.

Published In

Am J Respir Crit Care Med

DOI

EISSN

1535-4970

Publication Date

June 15, 2017

Volume

195

Issue

12

Start / End Page

1661 / 1670

Location

United States

Related Subject Headings

  • United States
  • Respiratory System
  • Precision Medicine
  • National Heart, Lung, and Blood Institute (U.S.)
  • Hypertension, Pulmonary
  • Humans
  • Education
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
  • 11 Medical and Health Sciences