Skip to main content
Journal cover image

Synovial fluid pro-inflammatory profile differs according to the characteristics of knee pain.

Publication ,  Journal Article
Leung, YY; Huebner, JL; Haaland, B; Wong, SBS; Kraus, VB
Published in: Osteoarthritis Cartilage
September 2017

OBJECTIVE: The role of inflammation and pain in osteoarthritis (OA) is not fully understood. We evaluated the association between pro-inflammatory biomarkers and pain. METHODS: We used baseline data and samples from a randomized controlled trial of colchicine for symptomatic knee OA. Severity of pain of the more symptomatic knee was assessed by National Health and Nutrition Examination Survey-I (NHANES-I) criterion and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain index. Pains on movement and at rest were self-reported on an 11-point Likert scale. Severity of radiographic tibiofemoral OA was assessed by Kellgren and Lawrence (KL) grade. Concentrations of synovial fluid (sf) IL-1β, IL-6, IL-8, TNFα, C-terminal telopeptides of Type I collagen (CTXI) and C-telopeptide of Type II collagen (CTXII), as well as urinary (u) CTXII were measured. RESULTS: Of the 109 patients enrolled in the study, 70 patients (70% women) with synovial fluid obtained by direct aspiration were included for analysis. The mean ± SD age and body mass index (BMI) of the patients were 57.6 ± 8.3 years and 28.8 ± 5.2 kg/m2. After adjustment for age, sex, and BMI, sf IL-6 and IL-8 were statistically significantly associated with 11-point pain on movement, but not with pain at rest. No significant associations were observed with WOMAC pain scores. sf IL-1β (analyzed as detectable/non-detectable) was inversely associated with pain. In contrast, after adjustment, Sf TNFα was associated with WOMAC total pain and both pain on movement and at rest. sf/u CTXII was associated with radiographic severity, but not with knee pain. CONCLUSIONS: This study provides indication that OA pain mechanisms may differ according to the characteristics of the pain.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Osteoarthritis Cartilage

DOI

EISSN

1522-9653

Publication Date

September 2017

Volume

25

Issue

9

Start / End Page

1420 / 1427

Location

England

Related Subject Headings

  • Young Adult
  • Synovial Fluid
  • Severity of Illness Index
  • Radiography
  • Pain Measurement
  • Pain
  • Osteoarthritis, Knee
  • Middle Aged
  • Male
  • Knee Joint
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Leung, Y. Y., Huebner, J. L., Haaland, B., Wong, S. B. S., & Kraus, V. B. (2017). Synovial fluid pro-inflammatory profile differs according to the characteristics of knee pain. Osteoarthritis Cartilage, 25(9), 1420–1427. https://doi.org/10.1016/j.joca.2017.04.001
Leung, Y. Y., J. L. Huebner, B. Haaland, S. B. S. Wong, and V. B. Kraus. “Synovial fluid pro-inflammatory profile differs according to the characteristics of knee pain.Osteoarthritis Cartilage 25, no. 9 (September 2017): 1420–27. https://doi.org/10.1016/j.joca.2017.04.001.
Leung YY, Huebner JL, Haaland B, Wong SBS, Kraus VB. Synovial fluid pro-inflammatory profile differs according to the characteristics of knee pain. Osteoarthritis Cartilage. 2017 Sep;25(9):1420–7.
Leung, Y. Y., et al. “Synovial fluid pro-inflammatory profile differs according to the characteristics of knee pain.Osteoarthritis Cartilage, vol. 25, no. 9, Sept. 2017, pp. 1420–27. Pubmed, doi:10.1016/j.joca.2017.04.001.
Leung YY, Huebner JL, Haaland B, Wong SBS, Kraus VB. Synovial fluid pro-inflammatory profile differs according to the characteristics of knee pain. Osteoarthritis Cartilage. 2017 Sep;25(9):1420–1427.
Journal cover image

Published In

Osteoarthritis Cartilage

DOI

EISSN

1522-9653

Publication Date

September 2017

Volume

25

Issue

9

Start / End Page

1420 / 1427

Location

England

Related Subject Headings

  • Young Adult
  • Synovial Fluid
  • Severity of Illness Index
  • Radiography
  • Pain Measurement
  • Pain
  • Osteoarthritis, Knee
  • Middle Aged
  • Male
  • Knee Joint