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Sequential Sterile Intraocular Inflammation Associated With Consecutive Intravitreal Injections of Aflibercept and Ranibizumab.

Publication ,  Journal Article
Grewal, DS; Schwartz, T; Fekrat, S
Published in: Ophthalmic Surg Lasers Imaging Retina
May 1, 2017

The authors report the unique response of two patients treated for cystoid macular edema (CME) secondary to central retinal vein occlusion (CRVO) who developed sequential episodes of likely sterile inflammatory responses following separate intravitreal injections of aflibercept (Eylea; Regeneron, Tarrytown, NY) and ranibizumab (Lucentis; Genentech, South San Francisco, CA) despite multiple previous uneventful injections for CME secondary to CRVO. Following the twenty-fifth aflibercept and seventh ranibizumab injection, two patients developed an acute inflammatory response, which was treated empirically with intravitreal antibiotics and topical and oral steroids (in Case 2). After an 8- to 10-week hiatus, they were switched over to ranibizumab and aflibercept, respectively, following which they developed a second episode of intraocular inflammation, treated similarly. Vitreous culture in one and aqueous culture in the other were deemed to represent contamination. Sterile intraocular inflammation, a known risk following injection with either aflibercept or ranibizumab, may develop sequentially in the same patient despite switching the drug. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:428-431.].

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Published In

Ophthalmic Surg Lasers Imaging Retina

DOI

EISSN

2325-8179

Publication Date

May 1, 2017

Volume

48

Issue

5

Start / End Page

428 / 431

Location

United States

Related Subject Headings

  • Visual Acuity
  • Uveitis
  • Tomography, Optical Coherence
  • Retinal Vein Occlusion
  • Recombinant Fusion Proteins
  • Receptors, Vascular Endothelial Growth Factor
  • Ranibizumab
  • Prodrugs
  • Prednisolone
  • Middle Aged
 

Citation

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Grewal, D. S., Schwartz, T., & Fekrat, S. (2017). Sequential Sterile Intraocular Inflammation Associated With Consecutive Intravitreal Injections of Aflibercept and Ranibizumab. Ophthalmic Surg Lasers Imaging Retina, 48(5), 428–431. https://doi.org/10.3928/23258160-20170428-10
Grewal, Dilraj S., Tayler Schwartz, and Sharon Fekrat. “Sequential Sterile Intraocular Inflammation Associated With Consecutive Intravitreal Injections of Aflibercept and Ranibizumab.Ophthalmic Surg Lasers Imaging Retina 48, no. 5 (May 1, 2017): 428–31. https://doi.org/10.3928/23258160-20170428-10.
Grewal DS, Schwartz T, Fekrat S. Sequential Sterile Intraocular Inflammation Associated With Consecutive Intravitreal Injections of Aflibercept and Ranibizumab. Ophthalmic Surg Lasers Imaging Retina. 2017 May 1;48(5):428–31.
Grewal, Dilraj S., et al. “Sequential Sterile Intraocular Inflammation Associated With Consecutive Intravitreal Injections of Aflibercept and Ranibizumab.Ophthalmic Surg Lasers Imaging Retina, vol. 48, no. 5, May 2017, pp. 428–31. Pubmed, doi:10.3928/23258160-20170428-10.
Grewal DS, Schwartz T, Fekrat S. Sequential Sterile Intraocular Inflammation Associated With Consecutive Intravitreal Injections of Aflibercept and Ranibizumab. Ophthalmic Surg Lasers Imaging Retina. 2017 May 1;48(5):428–431.

Published In

Ophthalmic Surg Lasers Imaging Retina

DOI

EISSN

2325-8179

Publication Date

May 1, 2017

Volume

48

Issue

5

Start / End Page

428 / 431

Location

United States

Related Subject Headings

  • Visual Acuity
  • Uveitis
  • Tomography, Optical Coherence
  • Retinal Vein Occlusion
  • Recombinant Fusion Proteins
  • Receptors, Vascular Endothelial Growth Factor
  • Ranibizumab
  • Prodrugs
  • Prednisolone
  • Middle Aged