Detecting association in a case-control study while correcting for population stratification.
Publication
, Journal Article
Reich, DE; Goldstein, DB
Published in: Genetic epidemiology
January 2001
Case-control studies are subject to the problem of population stratification, which can occur in ethnically mixed populations and can lead to significant associations being detected at loci that have nothing to do with disease. Here, we describe a way to measure and correct for stratification by genotyping a moderate number of unlinked genetic markers in the same set of cases and controls in which a candidate association was found. The average of association statistics across the markers directly measures stratification. By dividing the candidate association statistic by this average, a P-value can be obtained that corrects for stratification.
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Published In
Genetic epidemiology
DOI
EISSN
1098-2272
ISSN
0741-0395
Publication Date
January 2001
Volume
20
Issue
1
Start / End Page
4 / 16
Related Subject Headings
- Selection Bias
- Polymorphism, Single Nucleotide
- Models, Genetic
- Linkage Disequilibrium
- Humans
- Gene Frequency
- Ethnicity
- Epidemiology
- Chromosome Mapping
- Case-Control Studies
Citation
APA
Chicago
ICMJE
MLA
NLM
Reich, D. E., & Goldstein, D. B. (2001). Detecting association in a case-control study while correcting for population stratification. Genetic Epidemiology, 20(1), 4–16. https://doi.org/10.1002/1098-2272(200101)20:1<4::aid-gepi2>3.0.co;2-t
Reich, D. E., and D. B. Goldstein. “Detecting association in a case-control study while correcting for population stratification.” Genetic Epidemiology 20, no. 1 (January 2001): 4–16. https://doi.org/10.1002/1098-2272(200101)20:1<4::aid-gepi2>3.0.co;2-t.
Reich DE, Goldstein DB. Detecting association in a case-control study while correcting for population stratification. Genetic epidemiology. 2001 Jan;20(1):4–16.
Reich, D. E., and D. B. Goldstein. “Detecting association in a case-control study while correcting for population stratification.” Genetic Epidemiology, vol. 20, no. 1, Jan. 2001, pp. 4–16. Epmc, doi:10.1002/1098-2272(200101)20:1<4::aid-gepi2>3.0.co;2-t.
Reich DE, Goldstein DB. Detecting association in a case-control study while correcting for population stratification. Genetic epidemiology. 2001 Jan;20(1):4–16.
Published In
Genetic epidemiology
DOI
EISSN
1098-2272
ISSN
0741-0395
Publication Date
January 2001
Volume
20
Issue
1
Start / End Page
4 / 16
Related Subject Headings
- Selection Bias
- Polymorphism, Single Nucleotide
- Models, Genetic
- Linkage Disequilibrium
- Humans
- Gene Frequency
- Ethnicity
- Epidemiology
- Chromosome Mapping
- Case-Control Studies