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A SMAP in the face for cancer.

Publication ,  Journal Article
Shenolikar, S
Published in: J Clin Invest
June 1, 2017

Observed deficits in protein phosphatase 2A (PP2A) function in a variety of human cancers have stimulated drug discovery efforts aimed at restoring PP2A function to inhibit tumor growth. Work published by Sangodkar et al. in this issue of the JCI describes the characterization of orally available small molecule activators of PP2A (SMAPs). These SMAPs attenuated mitogenic signaling and triggered apoptosis in KRAS-mutant lung cancer cells and inhibited tumor growth in murine models. Tumors with mutations in the SMAP-binding site of the PP2A A subunit displayed resistance to SMAPs. Future studies that identify the PP2A-regulated events targeted by SMAPs should guide critical decisions about which cancers might be best treated with these molecules. This study provides encouraging evidence in favor of SMAPs as potential anticancer drugs.

Duke Scholars

Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

June 1, 2017

Volume

127

Issue

6

Start / End Page

2048 / 2050

Location

United States

Related Subject Headings

  • Signal Transduction
  • Protein Phosphatase 2
  • Mice
  • Lung Neoplasms
  • Immunology
  • Humans
  • Apoptosis
  • Antineoplastic Agents
  • Animals
  • 42 Health sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shenolikar, S. (2017). A SMAP in the face for cancer. J Clin Invest, 127(6), 2048–2050. https://doi.org/10.1172/JCI94763
Shenolikar, Shirish. “A SMAP in the face for cancer.J Clin Invest 127, no. 6 (June 1, 2017): 2048–50. https://doi.org/10.1172/JCI94763.
Shenolikar S. A SMAP in the face for cancer. J Clin Invest. 2017 Jun 1;127(6):2048–50.
Shenolikar, Shirish. “A SMAP in the face for cancer.J Clin Invest, vol. 127, no. 6, June 2017, pp. 2048–50. Pubmed, doi:10.1172/JCI94763.
Shenolikar S. A SMAP in the face for cancer. J Clin Invest. 2017 Jun 1;127(6):2048–2050.

Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

June 1, 2017

Volume

127

Issue

6

Start / End Page

2048 / 2050

Location

United States

Related Subject Headings

  • Signal Transduction
  • Protein Phosphatase 2
  • Mice
  • Lung Neoplasms
  • Immunology
  • Humans
  • Apoptosis
  • Antineoplastic Agents
  • Animals
  • 42 Health sciences