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Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease.

Publication ,  Journal Article
Nagel, ZD; Engelward, BP; Brenner, DJ; Begley, TJ; Sobol, RW; Bielas, JH; Stambrook, PJ; Wei, Q; Hu, JJ; Terry, MB; Dilworth, C; Reinlib, L ...
Published in: Mutat Res
August 2017

The rise of advanced technologies for characterizing human populations at the molecular level, from sequence to function, is shifting disease prevention paradigms toward personalized strategies. Because minimization of adverse outcomes is a key driver for treatment decisions for diseased populations, developing personalized therapy strategies represent an important dimension of both precision medicine and personalized prevention. In this commentary, we highlight recently developed enabling technologies in the field of DNA damage, DNA repair, and mutagenesis. We propose that omics approaches and functional assays can be integrated into population studies that fuse basic, translational and clinical research with commercial expertise in order to accelerate personalized prevention and treatment of cancer and other diseases linked to aberrant responses to DNA damage. This collaborative approach is generally applicable to efforts to develop data-driven, individualized prevention and treatment strategies for other diseases. We also recommend strategies for maximizing the use of biological samples for epidemiological studies, and for applying emerging technologies to clinical applications.

Duke Scholars

Published In

Mutat Res

DOI

EISSN

1873-135X

Publication Date

August 2017

Volume

800-802

Start / End Page

14 / 28

Location

Netherlands

Related Subject Headings

  • Precision Medicine
  • Oncology & Carcinogenesis
  • Neoplasms
  • Mutagenesis
  • Humans
  • DNA Repair
  • DNA Damage
  • 3105 Genetics
 

Citation

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ICMJE
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Nagel, Z. D., Engelward, B. P., Brenner, D. J., Begley, T. J., Sobol, R. W., Bielas, J. H., … Shaughnessy, D. T. (2017). Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease. Mutat Res, 800802, 14–28. https://doi.org/10.1016/j.mrfmmm.2017.03.007
Nagel, Zachary D., Bevin P. Engelward, David J. Brenner, Thomas J. Begley, Robert W. Sobol, Jason H. Bielas, Peter J. Stambrook, et al. “Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease.Mutat Res 800–802 (August 2017): 14–28. https://doi.org/10.1016/j.mrfmmm.2017.03.007.
Nagel ZD, Engelward BP, Brenner DJ, Begley TJ, Sobol RW, Bielas JH, et al. Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease. Mutat Res. 2017 Aug;800–802:14–28.
Nagel, Zachary D., et al. “Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease.Mutat Res, vol. 800–802, Aug. 2017, pp. 14–28. Pubmed, doi:10.1016/j.mrfmmm.2017.03.007.
Nagel ZD, Engelward BP, Brenner DJ, Begley TJ, Sobol RW, Bielas JH, Stambrook PJ, Wei Q, Hu JJ, Terry MB, Dilworth C, McAllister KA, Reinlib L, Worth L, Shaughnessy DT. Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease. Mutat Res. 2017 Aug;800–802:14–28.

Published In

Mutat Res

DOI

EISSN

1873-135X

Publication Date

August 2017

Volume

800-802

Start / End Page

14 / 28

Location

Netherlands

Related Subject Headings

  • Precision Medicine
  • Oncology & Carcinogenesis
  • Neoplasms
  • Mutagenesis
  • Humans
  • DNA Repair
  • DNA Damage
  • 3105 Genetics