The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors.
Publication
, Journal Article
Smith, JS; Rajagopal, S
Published in: J Biol Chem
April 22, 2016
The β-arrestins (βarrs) are versatile, multifunctional adapter proteins that are best known for their ability to desensitize G protein-coupled receptors (GPCRs), but also regulate a diverse array of cellular functions. To signal in such a complex fashion, βarrs adopt multiple conformations and are regulated at multiple levels to differentially activate downstream pathways. Recent structural studies have demonstrated that βarrs have a conserved structure and activation mechanism, with plasticity of their structural fold, allowing them to adopt a wide array of conformations. Novel roles for βarrs continue to be identified, demonstrating the importance of these dynamic regulators of cellular signaling.
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Published In
J Biol Chem
DOI
EISSN
1083-351X
Publication Date
April 22, 2016
Volume
291
Issue
17
Start / End Page
8969 / 8977
Location
United States
Related Subject Headings
- Signal Transduction
- Receptors, G-Protein-Coupled
- Protein Conformation
- Humans
- Biochemistry & Molecular Biology
- Arrestin
- Animals
- 34 Chemical sciences
- 32 Biomedical and clinical sciences
- 31 Biological sciences
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Smith, J. S., & Rajagopal, S. (2016). The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors. J Biol Chem, 291(17), 8969–8977. https://doi.org/10.1074/jbc.R115.713313
Smith, Jeffrey S., and Sudarshan Rajagopal. “The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors.” J Biol Chem 291, no. 17 (April 22, 2016): 8969–77. https://doi.org/10.1074/jbc.R115.713313.
Smith JS, Rajagopal S. The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors. J Biol Chem. 2016 Apr 22;291(17):8969–77.
Smith, Jeffrey S., and Sudarshan Rajagopal. “The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors.” J Biol Chem, vol. 291, no. 17, Apr. 2016, pp. 8969–77. Pubmed, doi:10.1074/jbc.R115.713313.
Smith JS, Rajagopal S. The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors. J Biol Chem. 2016 Apr 22;291(17):8969–8977.
Published In
J Biol Chem
DOI
EISSN
1083-351X
Publication Date
April 22, 2016
Volume
291
Issue
17
Start / End Page
8969 / 8977
Location
United States
Related Subject Headings
- Signal Transduction
- Receptors, G-Protein-Coupled
- Protein Conformation
- Humans
- Biochemistry & Molecular Biology
- Arrestin
- Animals
- 34 Chemical sciences
- 32 Biomedical and clinical sciences
- 31 Biological sciences