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WE-G-134-04: Four-Dimensional Dual Cone-Beam CT (4D-DCBCT): Preliminary Experimental Results.

Publication ,  Journal Article
Li, H; Vergalasova, I; Giles, W; Bowsher, J; Yin, F
Published in: Med Phys
June 2013

PURPOSE: One of the major challenges for clinical implementation of 4D-CBCT is long scan time. This study aims to develop a 4D-DCBCT technique to improve the efficiency of 4D imaging (for motion management in radiation therapy). METHODS: A bench-top DCBCT system, which consists of two orthogonal 40x30cm flat panel detectors and two conventional x-ray tubes with two individual high-voltage generators, sharing the same rotational axis, was used to develop the technique. The x-ray source to detector distance was 150 cm and x-ray source to rotational axis distance was 100 cm for both subsystems. The dual CBCT system utilized 110° of projection data from one detector and 90° from the other, as opposed to a single CBCT utilizing 200° of projection data per each detector. Motion phantom studies were conducted to validate the efficiencies by comparing 4D images generated from 4D-DCBCT and 4D-CBCT. First, a simple sinusoidal profile was used to confirm the scan time reduction. Next, both irregular sinusoidal and patient-derived profiles were used to investigate the advantage of temporally correlated orthogonal projections due to a reduced scan time. Normalized mutual information (NMI) between 4D-DCBCT and 4D-CBCT was used for quantitative evaluation. RESULTS: For the simple sinusoidal profile, the average NMI for ten phases between two single 4D-CBCTs was 0.336, indicating the maximum NMI that can be achieved for this study. The average NMIs between 4D-DCBCT and each single 4D-CBCT were 0.331 and 0.320. For both irregular sinusoidal and patient-derived profiles, 4D-DCBCT generated phase images with less motion blurring when compared with single 4D-CBCT. CONCLUSION: The 4D-DCBCT provides an efficient 4D imaging technique for motion management. The scan time is approximately reduced by a factor of two. The temporally correlated orthogonal projections improved the image blur across 4D phase images.

Duke Scholars

Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

June 2013

Volume

40

Issue

6Part31

Start / End Page

512

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Li, H., Vergalasova, I., Giles, W., Bowsher, J., & Yin, F. (2013). WE-G-134-04: Four-Dimensional Dual Cone-Beam CT (4D-DCBCT): Preliminary Experimental Results. Med Phys, 40(6Part31), 512. https://doi.org/10.1118/1.4815673
Li, H., I. Vergalasova, W. Giles, J. Bowsher, and F. Yin. “WE-G-134-04: Four-Dimensional Dual Cone-Beam CT (4D-DCBCT): Preliminary Experimental Results.Med Phys 40, no. 6Part31 (June 2013): 512. https://doi.org/10.1118/1.4815673.
Li H, Vergalasova I, Giles W, Bowsher J, Yin F. WE-G-134-04: Four-Dimensional Dual Cone-Beam CT (4D-DCBCT): Preliminary Experimental Results. Med Phys. 2013 Jun;40(6Part31):512.
Li, H., et al. “WE-G-134-04: Four-Dimensional Dual Cone-Beam CT (4D-DCBCT): Preliminary Experimental Results.Med Phys, vol. 40, no. 6Part31, June 2013, p. 512. Pubmed, doi:10.1118/1.4815673.
Li H, Vergalasova I, Giles W, Bowsher J, Yin F. WE-G-134-04: Four-Dimensional Dual Cone-Beam CT (4D-DCBCT): Preliminary Experimental Results. Med Phys. 2013 Jun;40(6Part31):512.

Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

June 2013

Volume

40

Issue

6Part31

Start / End Page

512

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences