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SU-C-105-03: Progress Toward the Development of a Deformable Anthropomorphic 3D Dosimetric Phantom.

Publication ,  Journal Article
Juang, T; Das, S; Adamovics, J; Oldham, M
Published in: Med Phys
June 2013

PURPOSE: Previous work has demonstrated that Presage-Def, a deformable, polyurethane-based radiochromic 3D dosimeter, has strong potential for validating deformable image registration algorithms by tracking optically measured radiation patterns from the deformed shape to the non-deformed shape. Here we present recent investigations into the efficacy of variant Presage-Def formulations with a range of elastic properties in terms of increased dose sensitivity and post-irradiation stability. METHODS: Eleven formulations of Presage-Def were created from combinations of 3 elastic polyurethane matrices (Shore Hardness 10-20A and 30A) and 7 leuco dyes. Dose sensitivity for each formulation was determined by irradiating cuvettes from 0-8Gy and measuring change in optical density at 633nm. Sensitivity readings were tracked over time to determine stability. Complementary to the small volume studies, a 15.7cm diameter cylindrical Presage-Def deformable dosimeter was created incorporating two air cavities (4.0cm diameter) and a rigid high-Z spine-mimic insert (2.8cm diameter). The dosimeter was subjected to bilateral compression to demonstrate complex, non-uniform deformation, and also irradiated with an 8.6cm×7.4cm field and imaged with optical-CT to investigate feasibility of optical-CT dose readout in a heterogeneous phantom. RESULTS: Dose sensitivities ranged from 0.0004-0.0071ΔOD/(Gy*cm) versus 0.0032ΔOD/(Gy*cm) in the original formulation. Highest sensitivity and stability were both seen in formulation PD1 (#2 polyurethane, leuco dye 1-napthal-N,N-diethylamine LMG), which retained 98.6% initial sensitivity over 4 hours whereas the original dropped to 90.6% after 1 hour. X-ray CT images of the prototype phantom with and without compression demonstrated non-uniform deformation of Presage-Def and air cavity geometry while the rigid region remained constant. The irradiated field was clearly visible in 3D dose distributions obtained by optical-CT. CONCLUSION: A Presage-Def formulation was identified from 10 variants with improved dosimetric characteristics. Optical-CT dose readout was achieved in the prototype phantom, demonstrating feasibility of 3D dosimetry in a large deformable dosimeter containing air and rigid bone-mimic inserts. NIH R01CA100835.

Duke Scholars

Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

June 2013

Volume

40

Issue

6Part2

Start / End Page

83

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Juang, T., Das, S., Adamovics, J., & Oldham, M. (2013). SU-C-105-03: Progress Toward the Development of a Deformable Anthropomorphic 3D Dosimetric Phantom. Med Phys, 40(6Part2), 83. https://doi.org/10.1118/1.4813927
Juang, T., S. Das, J. Adamovics, and M. Oldham. “SU-C-105-03: Progress Toward the Development of a Deformable Anthropomorphic 3D Dosimetric Phantom.Med Phys 40, no. 6Part2 (June 2013): 83. https://doi.org/10.1118/1.4813927.
Juang T, Das S, Adamovics J, Oldham M. SU-C-105-03: Progress Toward the Development of a Deformable Anthropomorphic 3D Dosimetric Phantom. Med Phys. 2013 Jun;40(6Part2):83.
Juang, T., et al. “SU-C-105-03: Progress Toward the Development of a Deformable Anthropomorphic 3D Dosimetric Phantom.Med Phys, vol. 40, no. 6Part2, June 2013, p. 83. Pubmed, doi:10.1118/1.4813927.
Juang T, Das S, Adamovics J, Oldham M. SU-C-105-03: Progress Toward the Development of a Deformable Anthropomorphic 3D Dosimetric Phantom. Med Phys. 2013 Jun;40(6Part2):83.

Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

June 2013

Volume

40

Issue

6Part2

Start / End Page

83

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences