Skip to main content

WE-E-BRB-04: Quantitative Dose Tracking Enabled Through a Novel Deformable 3D Dosimeter.

Publication ,  Journal Article
Juang, T; Newton, J; Das, S; Adamovics, J; Oldham, M
Published in: Med Phys
June 2012

PURPOSE: To evaluate and investigate the feasibility of a new method for validating dose tracking algorithms in deforming tissues using a novel deformable 3D dosimeter. METHODS: A novel deformable 3D Presage dosimeter is reported consisting of a stretchy polyurethane matrix doped with radiochromic leuco-dye. Two deformable cylindrical dosimeters (6 cm diameter, 5 cm long) were manufactured and irradiated with a checkerboard arrangement of 5 mm square pencil beams created by MLC fields. One dosimeter was irradiated under lateral compression by 33% (6 cm down to 4 cm diameter) to simulate a deformed organ. A second control dosimeter was irradiated with the same checkerboard pattern but without deformation applied. High-resolution 3D dose distributions (isotropic 1 mm resolution) were obtained by optical-CT imaging. Physical dose deformation was quantified by comparing checkerboard pencil beam shapes and positions in the deformed and control dosimeters. RESULTS: Deformation of dose in the deformed dosimeter was clearly visible in all 3 dimensions. The deformed checkerboard dose pattern showed expansion of 16% - 46% along the axis of compression, with higher expansion observed in the central regions of the dosimeter. Perpendicular to the compression axis, the dose pattern contracted by 7% - 13%. Peak dose changes of -6% and +30% were observed parallel and perpendicular to the compression axis respectively. Dose response was linear from 0-8 Gy. CONCLUSIONS: Dose tracking was successfully quantified in a novel deforming 3D dosimeter. This capability has potential as a powerful new method for validating deformable dose tracking and registration algorithms. NCI R01CA100835.

Duke Scholars

Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

June 2012

Volume

39

Issue

6Part27

Start / End Page

3956

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Juang, T., Newton, J., Das, S., Adamovics, J., & Oldham, M. (2012). WE-E-BRB-04: Quantitative Dose Tracking Enabled Through a Novel Deformable 3D Dosimeter. Med Phys, 39(6Part27), 3956. https://doi.org/10.1118/1.4736146
Juang, T., J. Newton, S. Das, J. Adamovics, and M. Oldham. “WE-E-BRB-04: Quantitative Dose Tracking Enabled Through a Novel Deformable 3D Dosimeter.Med Phys 39, no. 6Part27 (June 2012): 3956. https://doi.org/10.1118/1.4736146.
Juang T, Newton J, Das S, Adamovics J, Oldham M. WE-E-BRB-04: Quantitative Dose Tracking Enabled Through a Novel Deformable 3D Dosimeter. Med Phys. 2012 Jun;39(6Part27):3956.
Juang, T., et al. “WE-E-BRB-04: Quantitative Dose Tracking Enabled Through a Novel Deformable 3D Dosimeter.Med Phys, vol. 39, no. 6Part27, June 2012, p. 3956. Pubmed, doi:10.1118/1.4736146.
Juang T, Newton J, Das S, Adamovics J, Oldham M. WE-E-BRB-04: Quantitative Dose Tracking Enabled Through a Novel Deformable 3D Dosimeter. Med Phys. 2012 Jun;39(6Part27):3956.

Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

June 2012

Volume

39

Issue

6Part27

Start / End Page

3956

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences