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3D Printing of a Double Network Hydrogel with a Compression Strength and Elastic Modulus Greater than those of Cartilage.

Publication ,  Journal Article
Yang, F; Tadepalli, V; Wiley, BJ
Published in: ACS biomaterials science & engineering
May 2017

This article demonstrates a two-step method to 3D print double network hydrogels at room temperature with a low-cost ($300) 3D printer. A first network precursor solution was made 3D printable via extrusion from a nozzle by adding a layered silicate to make it shear-thinning. After printing and UV-curing, objects were soaked in a second network precursor solution and UV-cured again to create interpenetrating networks of poly(2-acrylamido-2-methylpropanesulfonate) and polyacrylamide. By varying the ratio of polyacrylamide to cross-linker, the trade-off between stiffness and maximum elongation of the gel can be tuned to yield a compression strength and elastic modulus of 61.9 and 0.44 MPa, respectively, values that are greater than those reported for bovine cartilage. The maximum compressive (93.5 MPa) and tensile (1.4 MPa) strengths of the gel are twice that of previous 3D printed gels, and the gel does not deform after it is soaked in water. By 3D printing a synthetic meniscus from an X-ray computed tomography image of an anatomical model, we demonstrate the potential to customize hydrogel implants based on 3D images of a patient's anatomy.

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Published In

ACS biomaterials science & engineering

DOI

EISSN

2373-9878

ISSN

2373-9878

Publication Date

May 2017

Volume

3

Issue

5

Start / End Page

863 / 869

Related Subject Headings

  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering
 

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Yang, F., Tadepalli, V., & Wiley, B. J. (2017). 3D Printing of a Double Network Hydrogel with a Compression Strength and Elastic Modulus Greater than those of Cartilage. ACS Biomaterials Science & Engineering, 3(5), 863–869. https://doi.org/10.1021/acsbiomaterials.7b00094
Yang, Feichen, Vaibhav Tadepalli, and Benjamin J. Wiley. “3D Printing of a Double Network Hydrogel with a Compression Strength and Elastic Modulus Greater than those of Cartilage.ACS Biomaterials Science & Engineering 3, no. 5 (May 2017): 863–69. https://doi.org/10.1021/acsbiomaterials.7b00094.
Yang F, Tadepalli V, Wiley BJ. 3D Printing of a Double Network Hydrogel with a Compression Strength and Elastic Modulus Greater than those of Cartilage. ACS biomaterials science & engineering. 2017 May;3(5):863–9.
Yang, Feichen, et al. “3D Printing of a Double Network Hydrogel with a Compression Strength and Elastic Modulus Greater than those of Cartilage.ACS Biomaterials Science & Engineering, vol. 3, no. 5, May 2017, pp. 863–69. Epmc, doi:10.1021/acsbiomaterials.7b00094.
Yang F, Tadepalli V, Wiley BJ. 3D Printing of a Double Network Hydrogel with a Compression Strength and Elastic Modulus Greater than those of Cartilage. ACS biomaterials science & engineering. 2017 May;3(5):863–869.
Journal cover image

Published In

ACS biomaterials science & engineering

DOI

EISSN

2373-9878

ISSN

2373-9878

Publication Date

May 2017

Volume

3

Issue

5

Start / End Page

863 / 869

Related Subject Headings

  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering