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Potential Impact and Study Considerations of Metabolomics in Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association.

Publication ,  Journal Article
Cheng, S; Shah, SH; Corwin, EJ; Fiehn, O; Fitzgerald, RL; Gerszten, RE; Illig, T; Rhee, EP; Srinivas, PR; Wang, TJ; Jain, M ...
Published in: Circ Cardiovasc Genet
April 2017

Through the measure of thousands of small-molecule metabolites in diverse biological systems, metabolomics now offers the potential for new insights into the factors that contribute to complex human diseases such as cardiovascular disease. Targeted metabolomics methods have already identified new molecular markers and metabolomic signatures of cardiovascular disease risk (including branched-chain amino acids, select unsaturated lipid species, and trimethylamine-N-oxide), thus in effect linking diverse exposures such as those from dietary intake and the microbiota with cardiometabolic traits. As technologies for metabolomics continue to evolve, the depth and breadth of small-molecule metabolite profiling in complex systems continue to advance rapidly, along with prospects for ongoing discovery. Current challenges facing the field of metabolomics include scaling throughput and technical capacity for metabolomics approaches, bioinformatic and chemoinformatic tools for handling large-scale metabolomics data, methods for elucidating the biochemical structure and function of novel metabolites, and strategies for determining the true clinical relevance of metabolites observed in association with cardiovascular disease outcomes. Progress made in addressing these challenges will allow metabolomics the potential to substantially affect diagnostics and therapeutics in cardiovascular medicine.

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Published In

Circ Cardiovasc Genet

DOI

EISSN

1942-3268

Publication Date

April 2017

Volume

10

Issue

2

Location

United States

Related Subject Headings

  • United States
  • Microbiota
  • Metabolomics
  • Metabolome
  • Humans
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • American Heart Association
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

APA
Chicago
ICMJE
MLA
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Cheng, S., Shah, S. H., Corwin, E. J., Fiehn, O., Fitzgerald, R. L., Gerszten, R. E., … American Heart Association Council on Functional Genomics and Translational Biology; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Stroke Council, . (2017). Potential Impact and Study Considerations of Metabolomics in Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association. Circ Cardiovasc Genet, 10(2). https://doi.org/10.1161/HCG.0000000000000032
Cheng, Susan, Svati H. Shah, Elizabeth J. Corwin, Oliver Fiehn, Robert L. Fitzgerald, Robert E. Gerszten, Thomas Illig, et al. “Potential Impact and Study Considerations of Metabolomics in Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association.Circ Cardiovasc Genet 10, no. 2 (April 2017). https://doi.org/10.1161/HCG.0000000000000032.
Cheng S, Shah SH, Corwin EJ, Fiehn O, Fitzgerald RL, Gerszten RE, et al. Potential Impact and Study Considerations of Metabolomics in Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association. Circ Cardiovasc Genet. 2017 Apr;10(2).
Cheng, Susan, et al. “Potential Impact and Study Considerations of Metabolomics in Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association.Circ Cardiovasc Genet, vol. 10, no. 2, Apr. 2017. Pubmed, doi:10.1161/HCG.0000000000000032.
Cheng S, Shah SH, Corwin EJ, Fiehn O, Fitzgerald RL, Gerszten RE, Illig T, Rhee EP, Srinivas PR, Wang TJ, Jain M, American Heart Association Council on Functional Genomics and Translational Biology; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Stroke Council. Potential Impact and Study Considerations of Metabolomics in Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association. Circ Cardiovasc Genet. 2017 Apr;10(2).

Published In

Circ Cardiovasc Genet

DOI

EISSN

1942-3268

Publication Date

April 2017

Volume

10

Issue

2

Location

United States

Related Subject Headings

  • United States
  • Microbiota
  • Metabolomics
  • Metabolome
  • Humans
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • American Heart Association
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology