Skip to main content
Journal cover image

Building research in diet and cognition: The BRIDGE randomized controlled trial.

Publication ,  Journal Article
Tussing-Humphreys, L; Lamar, M; Blumenthal, JA; Babyak, M; Fantuzzi, G; Blumstein, L; Schiffer, L; Fitzgibbon, ML
Published in: Contemp Clin Trials
August 2017

Obesity has been linked to cognitive impairment, cognitive decline and dementia. Given that 38.5% of U.S. adults 60years and older are obese and these numbers are rapidly increasing, strategies to decouple obesity from cognitive decline are needed. Innovative lifestyle strategies that may postpone the onset of subclinical symptoms or even arrest the transition to overt dementia in at-risk individuals are critically needed. Poor diet is central to the development of obesity and diet may affect cognition. Adherence to a Mediterranean Diet (MedDiet) is associated with reduced risk of cognitive impairment and dementia. Furthermore, weight loss through caloric restriction improves cognitive function. This paper describes the Building Research in Diet and CoGnition (BRIDGE) study, a randomized trial examining the effect of the MedDiet, with and without weight loss, on cognitive functioning in obese older adults. Obese (BMI≥30 and ≤50kg/m2) older adults (≥55years) (n=180) will be randomized in a 2:2:1 allocation scheme to: Typical Diet Control; MedDiet alone, without weight loss; or MedDiet lifestyle intervention to promote weight loss and weight loss maintenance. Both MedDiet intervention groups will meet for one individual session and 27 group sessions over an 8-month period. Individuals in the control group will not receive instruction on changing lifestyle habits. Outcomes will be assessed at baseline, 8 and 14months. The primary outcome is cognitive functioning; secondary outcomes will include changes in body weight, diet, cardiovascular, metabolic, and inflammatory biomarkers.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Contemp Clin Trials

DOI

EISSN

1559-2030

Publication Date

August 2017

Volume

59

Start / End Page

87 / 97

Location

United States

Related Subject Headings

  • Weight Loss
  • Public Health
  • Outcome Assessment, Health Care
  • Obesity
  • Middle Aged
  • Male
  • Humans
  • Healthy Lifestyle
  • General Clinical Medicine
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Tussing-Humphreys, L., Lamar, M., Blumenthal, J. A., Babyak, M., Fantuzzi, G., Blumstein, L., … Fitzgibbon, M. L. (2017). Building research in diet and cognition: The BRIDGE randomized controlled trial. Contemp Clin Trials, 59, 87–97. https://doi.org/10.1016/j.cct.2017.06.003
Tussing-Humphreys, Lisa, Melissa Lamar, James A. Blumenthal, Michael Babyak, Giamila Fantuzzi, Lara Blumstein, Linda Schiffer, and Marian L. Fitzgibbon. “Building research in diet and cognition: The BRIDGE randomized controlled trial.Contemp Clin Trials 59 (August 2017): 87–97. https://doi.org/10.1016/j.cct.2017.06.003.
Tussing-Humphreys L, Lamar M, Blumenthal JA, Babyak M, Fantuzzi G, Blumstein L, et al. Building research in diet and cognition: The BRIDGE randomized controlled trial. Contemp Clin Trials. 2017 Aug;59:87–97.
Tussing-Humphreys, Lisa, et al. “Building research in diet and cognition: The BRIDGE randomized controlled trial.Contemp Clin Trials, vol. 59, Aug. 2017, pp. 87–97. Pubmed, doi:10.1016/j.cct.2017.06.003.
Tussing-Humphreys L, Lamar M, Blumenthal JA, Babyak M, Fantuzzi G, Blumstein L, Schiffer L, Fitzgibbon ML. Building research in diet and cognition: The BRIDGE randomized controlled trial. Contemp Clin Trials. 2017 Aug;59:87–97.
Journal cover image

Published In

Contemp Clin Trials

DOI

EISSN

1559-2030

Publication Date

August 2017

Volume

59

Start / End Page

87 / 97

Location

United States

Related Subject Headings

  • Weight Loss
  • Public Health
  • Outcome Assessment, Health Care
  • Obesity
  • Middle Aged
  • Male
  • Humans
  • Healthy Lifestyle
  • General Clinical Medicine
  • Female